Kyoto University researchers find spermidine inhibits tumor growth in mice by improving the mitochondrial function of anticancer immune cells.
Category: Cancer
New Study Suggests NR May Be Bad for Cancer Patients
Key Points: Nicotinamide riboside (NR) is a form of vitamin B3 found in milk, yeast, and other foods. In the last decade, it has been touted to have anti-aging benefits with minimal side effects. However, a recent study put forward evidence that NR may affect how cancer spreads to secondary areas in the body. The… Continue reading New Study Suggests NR May Be Bad for Cancer Patients
MCI Scientists Find NAD⁺ Boosting Agent Suppresses Brain Tumor Growth
Key Points: Combining the NAD+ precursor NRH with chemotherapy enhances the effect of reducing brain tumor cell growth. NRH raises NAD+ levels in brain tumor cells, suggesting that boosting NAD+ helps prevent tumor growth. The most common type of brain tumor is also the most lethal. Deadly tumors called glioblastomas spread rapidly in the brain… Continue reading MCI Scientists Find NAD⁺ Boosting Agent Suppresses Brain Tumor Growth
100% Rectal Cancer Remission through PD-1 Immunotherapy
Key Points: Complete remission of twelve rectal cancer patients was observed following 6 months of dostarlimab treatment according to visual examination (endoscopy, MRI, and PET scans). Patients had limited side effects, including nausea, fatigue, and itchy skin. Ten patients reached zero percent tumor progression after 6 months of treatment based on tissue samples. The unrestrained… Continue reading 100% Rectal Cancer Remission through PD-1 Immunotherapy
The Senolytic ABT-737 Halts Pancreatic Cancer Development in Mice
Key Points: Early stage pancreatic cancer cells contain senescent cells with high levels of Cox2 — an enzyme that promotes inflammation. Treatment with the senolytic drug ABT-737 eliminates these Cox2 senescent cells. Mice treated with ABT-737 exhibit significantly less precancerous growth in the pancreas, suggesting that eliminating Cox2 senescent cells halts the progression of cancer. … Continue reading The Senolytic ABT-737 Halts Pancreatic Cancer Development in Mice
Swiss Study Shows Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk
Key Points: Growing older accompanies impending cancer, a disease of aging second only to cardiovascular disease in leading to the most deaths in the United States. While diet and exercise are well-known preventative measures for cardiovascular disease, a new study suggests that such measures could also potentially reduce the risk of cancer. In the journal… Continue reading Swiss Study Shows Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk
UPenn Researchers Engineer Immune Cells that Restore Heart Function
Key Points: When our hearts succumb to injury, our cells kick into high gear and activate cells that make up our connective tissue (fibroblasts), generating fibrous scar tissue in a process known as fibrosis. However, the continual accumulation of fibrous scar tissue rigifies the heart muscle, diminishing overall performance and contributing to the development of… Continue reading UPenn Researchers Engineer Immune Cells that Restore Heart Function
Study Shows NAD⁺-Boosting Supplement Enhances Anti-Tumor Immunotherapy
Highlights Using CRISPR to screen critical genes in the cancer-eliminating immune response, researchers from ShanghaiTech University identify a role for NAD+ metabolism. Increasing NAD+ levels by supplementing with nicotinamide improves anti-cancer CAR-T immunotherapy in mice, extending their lifespans. This study establishes a conceptual basis for enhancing tumor immunotherapy through simple nutritional supplements that boost NAD+… Continue reading Study Shows NAD⁺-Boosting Supplement Enhances Anti-Tumor Immunotherapy
NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
T lymphocytes, a type of white blood cell, contribute to the body’s immune response against cancer. T lymphocyte antitumor responses are metabolically challenged when nutrients are depleted from the cellular microenvironment that tumors form, resulting in T cell malfunction. Researchers have yet to elucidate the mechanisms controlling the effects tumors have on T lymphocyte antitumor… Continue reading NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer
Uncontrollably growing cells can form tumors, and when tumors form, they are confronted and invaded by the body’s defense–the immune system. Yet tumors often disarm our protective immune cells, which renders them ineffective and eliminates their cancer cell killing capabilities. This is true for the deadly and highly incurable brain cancer called glioblastoma. So, finding… Continue reading Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer