Highlights Human lung cells are transformed into senescent “zombie cells” by SARS-CoV-2. Drugs called senolytics can eliminate these once infected lung cells that have become senescent. Coronavirus may accelerate aspects of aging by induction of senescent lung cells. Coronavirus (SARS-CoV-2) just doesn’t seem to go away, and even when it does, it continues to cause… Continue reading Coronavirus Creates Zombie Cells that Fuel Post-Acute COVID-19 Syndrome
Category: Basic Research
NAD⁺ Booster Improves Oocyte Quality
Key Points: Having a baby is complicated, and hopeful parents must take the necessary precautions to avoid complications. To conceive a healthy baby — with five fingers and five toes — countless events need to be executed flawlessly, from the joining of sperm and egg for fertilization to the proper development and birth of the… Continue reading NAD⁺ Booster Improves Oocyte Quality
NMN Limits Senescence of Vital Lung Cells
Highlights Senescence of lung cells called alveolar epithelial cells — critical for getting oxygen into the body — is alleviated by the NAD+ precursor NMN. The addition of NMN can effectively alleviate injury-induced senescence in lung cells from mice. Through breathing, we bring in oxygen, needed by all cells in our body to make energy,… Continue reading NMN Limits Senescence of Vital Lung Cells
Fluctuating Molecule Levels in the Blood May Indicate Signs of Aging
Previous research has shown that aging can be combatted through metabolite supplementation in addition to restricting calorie intake, which can be achieved via an altered diet that diminishes daily average calorie intake. Organisms such as flies, fish, mice, and spiders have all displayed a 20% or more increase in lifespan when daily calorie intake is… Continue reading Fluctuating Molecule Levels in the Blood May Indicate Signs of Aging
CD38 Enzymes on Immune Cell Surfaces Drive Declining NAD⁺ Levels with Age
Nicotinamide adenine dinucleotide (NAD+) is an essential energy-producing molecule and plays a crucial role in maintaining DNA integrity. Levels of NAD+ in cells decrease upon aging, and scientists have connected these age-induced decreases in NAD+ to the development of Alzheimer’s disease, metabolic disorders, and cardiovascular dysfunction. CD38 is an enzyme that has been demonstrated to… Continue reading CD38 Enzymes on Immune Cell Surfaces Drive Declining NAD⁺ Levels with Age
The Cell Compartment Subdivision of NAD⁺ is Critical to Mammalian Life
The roles of the vital molecule nicotinamide adenine dinucleotide (NAD+) in cells are organized and coordinated based on how it’s subdivided into different structures within cells. The molecule’s distribution inside the cells is critical to understanding NAD+’s impact on biological processes, diseases, and aging. Investigators from the University of Texas at Austin and the University… Continue reading The Cell Compartment Subdivision of NAD⁺ is Critical to Mammalian Life
Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments
Chimeric antigen receptor (CAR) T cells, genetically altered immune cells extracted from patients and subsequently reintroduced, have obtained notoriety for treating blood malignancies. However, is it possible to utilize these cells to combat conditions like aging? In a study published in the journal Nature, Lowe and colleagues from Sloan Kettering Institute in New York demonstrated… Continue reading Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments