Key Points: Several critical processes during prenatal development must be executed to produce healthy offspring. However, these events require healthy, viable egg cells, which drastically decline in quality upon aging. Notably, current data indicate that women now have children at later stages of life, which has driven scientists to develop safe and effective therapeutics to… Continue reading New Study Shows Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline
Category: Basic Research
Study Suggests Tomato Antioxidant Prevents Signs of Diabetes and Reverses Blood Vessel Aging
Key Points: Supplementing aged rats with lycopene increases the growth of blood vessels in muscle. Blood vessel growth is induced by reduced insulin resistance — a primary cause of type 2 diabetes — allowing for improved glucose (energy) utilization. Blood vessel restoration is regulated by SIRT1, a guardian protein that plays a vital role in… Continue reading Study Suggests Tomato Antioxidant Prevents Signs of Diabetes and Reverses Blood Vessel Aging
Senolytics Restore Bone Healing Capacity in Older Age
Key Points: Senescent cells – cells that underlie many age-related diseases – populate in response to bone fracture in aged mice. Senolytic treatment – which eliminates senescent cells – leads to accelerated healing at the wound site. Treatment with senolytics restores the stem cell and bone growth squandered by senescent cells. In the case of… Continue reading Senolytics Restore Bone Healing Capacity in Older Age
University of Washington Study Identifies New Age-Reversing Drug Cocktail
Key Points: Combined treatment with rapamycin, acarbose, and phenylbutyrate leads to a reduction in fat mass in aged mice. The combined treatment cocktail improves learning, as well as endurance and strength. Age-related heart, lung, liver, and kidney lesions are reduced by the treatment cocktail. We often think of aging as one process, but multiple biological… Continue reading University of Washington Study Identifies New Age-Reversing Drug Cocktail
Study Shows that Curcumin Improves Learning and Memory in Older Mice
Key Points: Curcumin treatment improves age-related spatial learning and memory deficits. Treatment with curcumin enhances neuroplasticity. Brain inflammation and oxidative stress are reduced by curcumin treatment. If there were a region of our brain that set us apart from all other animals, it would be the prefrontal cortex. Our prefrontal cortex integrates sensory information to… Continue reading Study Shows that Curcumin Improves Learning and Memory in Older Mice
Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
Key Points: Sperm exposure to metformin — a diabetes medication — three months before conception leads to increased birth defects. The frequency of metformin-induced birth defects was higher than birth defects from treatment with insulin or the type 2 diabetes medication sulfonylurea. Conception during metformin exposure was less likely to result in male offspring. When… Continue reading Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
NAD⁺ Restores Essential Clock for Muscle Repair
Key Points: Circadian clock malfunction hinders muscle repair by inhibiting the formation of new muscle cells after injury. Dysfunctional muscle formation is due to a shift from glucose to fat metabolism, reducing NAD+ levels. Boosting NAD+ restores SIRT1 gene modulation and muscle cell formation. Molecular clocks control many of our body’s biological processes, from our… Continue reading NAD⁺ Restores Essential Clock for Muscle Repair
Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Key Points: Obesity due to a high-fat diet causes subfertility – fewer mature oocytes (eggs) and smaller litters in mice. Supplementing with nicotinamide riboside (NR), an NAD+ precursor, alleviates the obesity-induced subfertility. These findings suggest that NAD+ boosting through precursor supplementation could be a potential therapy for diet-induced subfertility. Infertility is on the rise, currently… Continue reading Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
What Drives Aging?
Key Points: NAD+ declines with age largely due to the activation of CD38, an enzyme activated by the inflammation produced by senescent cells – cells that no longer grow or replicate. In a feed-forward cycle, the decline of NAD+ by CD38 induces the spread of more senescent cells and inflammation. Halting this cycle could prevent… Continue reading What Drives Aging?
Senolytic Improves Age-Related Memory Loss
Highlights Neurogenesis declines and senescent “zombie” cells accumulate with age in the hippocampus, a brain region associated with learning and memory. A drug that destroys senescent cells, ABT-263, restores neurogenesis in the hippocampus by rejuvenating brain stem cells. Likely through this mechanism, ABT-263 enhances learning and memory in middle-aged mice. It is becoming increasingly apparent… Continue reading Senolytic Improves Age-Related Memory Loss