Key Points: Published in Cell Reports, Apte and colleagues from Washington University School of Medicine in St. Louis provide data suggesting that cellular NAD+ depletion leads to senescence, at least in white blood cells called macrophages in mice. They also show that, in macrophages, falling cellular NAD+ and senescence propel age-related macular degeneration (AMD) —… Continue reading Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings
Category: Immunity
Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells
Key Points: Researchers at Sichuan University and the Chinese Academy of Sciences came up with a way to find and kill cells that are known to cause aging and diseases linked to aging. The scientists describe how they made an immune cell that targets a specific protein called Natural Killer Group 2 Member D (NKG2D)… Continue reading Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells
Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study
Key Points: If worrying about what to eat was not enough, studies indicate that when to eat is important for healthy aging as well. However, this may not be complicated, as a new study from the Universidad Católica de Murcia in Spain reveals. In the study, published in Nutrients, Delgado-Alarcon and colleagues showed that inflammatory… Continue reading Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study
Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility
Key Points: A woman’s reproductive lifespan is largely determined by her ovarian reserve — a finite number of oocytes that decreases with age. Declining oocyte numbers inevitably hampers fertility, which usually occurs during a woman’s late 30s. However, scientists from the Buck Institute in California believe that reproductive lifespan can be prolonged, which could also… Continue reading Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility
Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells
Key Points: Researchers at Sichuan University and the Chinese Academy of Sciences came up with a way to find and kill cells that are known to cause aging and diseases linked to aging. The scientists describe how they made an immune cell that targets a specific protein called Natural Killer Group 2 Member D (NKG2D)… Continue reading Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells
Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds
Key Points: Research at the Ludwig Institute for Cancer Research at the University of Lausanne shows that a molecule called urolithin A can make old blood stem cells better at making blood and immune systems. Blood stem cells from old people were given Urolithin A for three days, which made them better able to grow… Continue reading Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds
Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation
Key Points: While our immune system guards us from bacterial infection, it progressively falters with age. By the time we grow old, our immune system becomes more likely to evoke a life-threatening inflammatory response — sepsis — when threatened by bacterial invaders. However, researchers from Harvard and the Huntington Medical Research Institute may have found… Continue reading Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation
Japanese Study Links Radiation with Accelerated Immune Aging: Nuclear Power’s Lasting Impact
Key Points: The immune system gradually declines with age leading to chronic inflammation, a major driver of age-related diseases, including cardiovascular disease, cancer, and diabetes. Now researchers from the Radiation Effects Research Foundation in Japan have found that immune system aging may be accelerated by radiation from the atomic bomb Dr. Oppenheimer — the father… Continue reading Japanese Study Links Radiation with Accelerated Immune Aging: Nuclear Power’s Lasting Impact
Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume
Key Points: Can cells avoid aging, or is aging an unavoidable, programmed fate? A new study published in Nature shows that descendents from immune cells can be continuously harvested and transferred into new mice for over 10 years, which is about four times the lifespan of a mouse. Despite demonstrating the potential to expand the… Continue reading Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume
Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺
Key Points: C3G, a molecule that gives some fruits their deep purple hue, is a natural inhibitor of CD38 — an enzyme on the surface of our immune cells. While CD38 is a critical component of our immune system, it becomes overactive with aging. And since CD38 depletes NAD+, its overactivity may be the primary… Continue reading Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺