Key Points: Due to the nuances of the original description being lost, “inflamm-aging” is often erroneously described as chronic, sterile, low-grade inflammation. However, while the original description characterizes chronic, sterile low-grade inflammation as an inevitable consequence of aging, it is not the sole determinant of age-related disability. That is, whether inflammation leads to disability is… Continue reading What Is Inflammaging? And How to Reverse It
Category: Immunity
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NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice
Key Points: Blood stem cells help our bodies repair and grow new tissues all through our lives, and scientists have found a way to keep them from dying off too quickly as we get older. Getting rid of or blocking an enzyme that breaks down NAD+, a molecule important for keeping stem cells young, can… Continue reading NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice
Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings
Key Points: Published in Cell Reports, Apte and colleagues from Washington University School of Medicine in St. Louis provide data suggesting that cellular NAD+ depletion leads to senescence, at least in white blood cells called macrophages in mice. They also show that, in macrophages, falling cellular NAD+ and senescence propel age-related macular degeneration (AMD) —… Continue reading Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings
Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells
Key Points: Researchers at Sichuan University and the Chinese Academy of Sciences came up with a way to find and kill cells that are known to cause aging and diseases linked to aging. The scientists describe how they made an immune cell that targets a specific protein called Natural Killer Group 2 Member D (NKG2D)… Continue reading Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells
Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study
Key Points: If worrying about what to eat was not enough, studies indicate that when to eat is important for healthy aging as well. However, this may not be complicated, as a new study from the Universidad Católica de Murcia in Spain reveals. In the study, published in Nutrients, Delgado-Alarcon and colleagues showed that inflammatory… Continue reading Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study
Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility
Key Points: A woman’s reproductive lifespan is largely determined by her ovarian reserve — a finite number of oocytes that decreases with age. Declining oocyte numbers inevitably hampers fertility, which usually occurs during a woman’s late 30s. However, scientists from the Buck Institute in California believe that reproductive lifespan can be prolonged, which could also… Continue reading Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility
Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells
Key Points: Researchers at Sichuan University and the Chinese Academy of Sciences came up with a way to find and kill cells that are known to cause aging and diseases linked to aging. The scientists describe how they made an immune cell that targets a specific protein called Natural Killer Group 2 Member D (NKG2D)… Continue reading Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells
Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds
Key Points: Research at the Ludwig Institute for Cancer Research at the University of Lausanne shows that a molecule called urolithin A can make old blood stem cells better at making blood and immune systems. Blood stem cells from old people were given Urolithin A for three days, which made them better able to grow… Continue reading Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds
Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation
Key Points: While our immune system guards us from bacterial infection, it progressively falters with age. By the time we grow old, our immune system becomes more likely to evoke a life-threatening inflammatory response — sepsis — when threatened by bacterial invaders. However, researchers from Harvard and the Huntington Medical Research Institute may have found… Continue reading Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation