Key Points: The aging research field has produced a number of new, groundbreaking anti-aging technologies over the last few years. Among these, nicotinamide adenine dinucleotide (NAD+) precursors, such as NMN and NR, which counteract falling NAD+ levels during aging, can be used to combat possible causative factors of aging. Reviewing possible causative factors contributing to… Continue reading Pinpointing the Causes of Aging: Sifting Through Prevailing Theories
Category: Epigenetics
David Sinclair: DNA Tagging, rather than DNA Damage, Drives Aging and Is Reversible
Key Points: Information storage and retrieval is not only a cornerstone of technology like telecommunications and the internet but also a fundamental aspect of life. Every complex organism, from plants to humans, relies on the intricate information encoded in DNA. This DNA acts as a blueprint for protein production, essential for all biological functions. Beyond… Continue reading David Sinclair: DNA Tagging, rather than DNA Damage, Drives Aging and Is Reversible
The Emergence of Cellular Reprogramming: True Age Reversal Technology
Contents Why Do We Age? Reversing Aging with Cellular Reprogramming How Does Cellular Reprogramming Work? Biological Clocks Partial Epigenetic Reprogramming Delivering Yamanaka Factors via Gene Therapy How Effective is Cellular Reprogramming? Reprogramming Extends Mouse Lifespan Reprogramming Reverses Aging When will Cellular Reprogramming Reach Consumers? Why Do We Age? Scientists are unable to agree upon the… Continue reading The Emergence of Cellular Reprogramming: True Age Reversal Technology
David Sinclair: “Age Reversal Works in Primates to Restore Vision” and Humans are Next
Key Points: On April 23rd, 2023, data was presented at the annual Association for Research in Vision and Ophthalmology (ARVO) conference in New Orleans showing that a new gene therapy utilizing partial (epigenetic) reprogramming restores visual function in nonhuman primates. Harvard professor, cofounder of Life Biosciences, and co-author of the study said: “Demonstrating rejuvenation in… Continue reading David Sinclair: “Age Reversal Works in Primates to Restore Vision” and Humans are Next
Harvard and Duke Study Shows Stressful Events Accelerate Biological Aging
Key Points: We all experience stress. Whether it be from work, relationships, financial concerns, or health issues, it’s a normal aspect of modern life. While chronic stress is known to contribute to accelerated aging and age-related disease, the effect of acute, highly stressful events on biological aging is not well understood. Now, researchers from Harvard… Continue reading Harvard and Duke Study Shows Stressful Events Accelerate Biological Aging
Age-Reversing Technology Promotes Heart Repair After Heart Attack: German Study
Key Points: The muscle cells that allow our heart to pump blood — cardiomyocytes (CMs) — have little regenerative capacity, making it difficult for the heart to recover from injury or disease. However, scientists from the Max Planck Institute may have found a way to restore this regenerative capacity. Chen and colleagues report in Science that… Continue reading Age-Reversing Technology Promotes Heart Repair After Heart Attack: German Study
Harvard Study Supports David Sinclair’s Theory: Altered Gene Programming is Root Cause of Aging
Key Points: Not all our DNA is accessible to the machinery of our cells, and for good reason. We don’t want our muscle cells to access genes meant for immune cells, and we don’t want our skin cells to access the blueprint for neurons. Otherwise, we may have a cell identity crisis, whereby muscle cells… Continue reading Harvard Study Supports David Sinclair’s Theory: Altered Gene Programming is Root Cause of Aging
Study Suggests We are Now Closer to Reversing Aging via Gene Therapy
Key Points: Age reversal refers to restoring an organism’s youth. This includes prolonging the organism’s lifespan and healthspan — the duration of life lived without disease and age-related deficits. One of the more ambitious goals of aging science is to reverse aging in humans, and a new study suggests we are one step closer to doing just… Continue reading Study Suggests We are Now Closer to Reversing Aging via Gene Therapy
Study Shows Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal
Key Points: Aging leads to changes in gene activation linked to brain function in the hippocampus of mice. Rapamycin restores 69.5% of the same age-associated gene changes as dietary restriction. Dietary restriction restores more age-associated genes than rapamycin. For those of us who wish to live longer, the two most powerful methods for extending lifespan… Continue reading Study Shows Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal
Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Several age-related studies seek to understand how gene regulation is affected by methyl groups, which are compounds known to attach to DNA via a process called methylation. Decreases in gene activation are associated with increases in methylation. As humans age, methylation patterns diverge, and cells end up reading incorrect genes, promoting age-related diseases and malfunctional… Continue reading Reversing Age-Related Vision Loss with Embryonic Gene Delivery