Key Points: Not all our DNA is accessible to the machinery of our cells, and for good reason. We don’t want our muscle cells to access genes meant for immune cells, and we don’t want our skin cells to access the blueprint for neurons. Otherwise, we may have a cell identity crisis, whereby muscle cells… Continue reading Harvard Study Supports David Sinclair’s Theory: Altered Gene Programming is Root Cause of Aging
Category: Epigenetics
Study Suggests We are Now Closer to Reversing Aging via Gene Therapy
Key Points: Age reversal refers to restoring an organism’s youth. This includes prolonging the organism’s lifespan and healthspan — the duration of life lived without disease and age-related deficits. One of the more ambitious goals of aging science is to reverse aging in humans, and a new study suggests we are one step closer to doing just… Continue reading Study Suggests We are Now Closer to Reversing Aging via Gene Therapy
Study Shows Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal
Key Points: Aging leads to changes in gene activation linked to brain function in the hippocampus of mice. Rapamycin restores 69.5% of the same age-associated gene changes as dietary restriction. Dietary restriction restores more age-associated genes than rapamycin. For those of us who wish to live longer, the two most powerful methods for extending lifespan… Continue reading Study Shows Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal
Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Several age-related studies seek to understand how gene regulation is affected by methyl groups, which are compounds known to attach to DNA via a process called methylation. Decreases in gene activation are associated with increases in methylation. As humans age, methylation patterns diverge, and cells end up reading incorrect genes, promoting age-related diseases and malfunctional… Continue reading Reversing Age-Related Vision Loss with Embryonic Gene Delivery