Key Points: As published in Communications Medicine, Pike and colleagues from the University of Southern California in Los Angeles find that in genetically engineered mice with the human version of a DNA sequence predisposing to dementia and accelerated aging (APOE4), treating with alfatradiol improves scores on an assessment of age-related physical decline (frailty index score).… Continue reading USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s
Category: Brain & Neurons
Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging
Key Points: While eating less (caloric restriction or fasting) clearly benefits longevity and health, sustaining such a restrictive diet can be difficult and unpleasant. For these reasons, scientists have searched for compounds capable of recapitulating the benefits of consuming fewer calories, so far identifying several promising candidates, including spermidine. Mouse studies have shown that spermidine… Continue reading Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging
Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study
Key Points: As published in a non-peer-reviewed preprint, Sadagurski and colleagues from Wayne State University in Detroit show that the diabetes drug canagliflozin enhances learning and memory in middle-aged male mice. Further analyses of canagliflozin’s effects on gene expression, protein levels, and metabolic markers revealed that canagliflozin enhances mitochondrial function and suppresses neuroinflammation in middle-aged… Continue reading Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study
New Study Suggests NR Modestly Improves Cognition in Human Subjects
Key Points: Peripheral artery disease (PAD) is an age-related condition where arteries that carry blood to the limbs, especially the legs and feet, become narrowed or blocked by plaque buildup. This reduced blood flow can cause pain, numbness, and is even associated with impaired cognitive function. As published in the Journal of Pharmacology and Experimental… Continue reading New Study Suggests NR Modestly Improves Cognition in Human Subjects
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Creatine Supplement Improves Memory in People with Alzheimer’s: New Pilot Study
Key Points: When most people hear “creatine,” they think of bodybuilders and athletes looking to enhance their performance. This naturally occurring compound has been a staple in fitness communities for decades, primarily known for improving muscle strength and exercise capacity. But what if this same supplement could help power something even more important—our brain cells?… Continue reading Creatine Supplement Improves Memory in People with Alzheimer’s: New Pilot Study
Targeting NAD+ for Treating Dementia: New Harvard Op-Ed
Key Points: In 2024, 3.8 billion US tax dollars went towards researching Alzheimer’s disease (AD) via the National Institute of Health (NIH). However, there are still no adequate treatments for AD, and scientists have yet to agree upon its root cause. In a recent publication, Harvard Medical School researchers Kai-Christian Sonntag, MD, PhD, and Bruce… Continue reading Targeting NAD+ for Treating Dementia: New Harvard Op-Ed
New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging
Key Points: A landmark study from Mujica-Parodi and colleagues of the State University of New York at Stony Brook, published in PNAS, suggests that brain aging follows a distinct, non-linear trajectory, beginning in people’s 40s. The researchers also unveiled a correlation between neuronal insulin resistance—where cells begin to lose the ability to use glucose—and the… Continue reading New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging
Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows
Key Points: Brain aging is intricately linked to immune system aging, whereby a compromised immune system disrupts brain function, leading to cognitive decline and neurodegenerative diseases like Alzheimer’s disease (AD). However, about 30 years ago, making this link amongst neuroscientists and immunologists would have had you laughed out of the room. It wasn’t until 1998… Continue reading Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows
Accessing Technology that Reduces Alzheimer’s Memory Loss by 52%
Key Points: The results of a Phase II clinical trial, published in Alzheimer’s Research & Therapy, reveal that 52 weeks of TMS treatment mitigates cognitive decline, independence loss, and behavioral disturbances in Alzheimer’s disease (AD) patients. With no serious side effects associated with the treatment, this approach is more effective and safer than the drugs… Continue reading Accessing Technology that Reduces Alzheimer’s Memory Loss by 52%