Key Points: Cellular nicotinamide adenine dinucleotide (NAD+) levels decline as we grow older. Based on its role in a multitude of cellular processes, including energy generation and DNA repair, falling concentrations of this essential molecule correlate with the onset of age-related conditions like cardiovascular disease and metabolic disorders. Finding new ways to counteract lower NAD+… Continue reading Enhancing Longevity-Promoting Cocktails: Combining Micronutrients with NAD+ Precursors to Maximize Their Effects
Category: Reviews
Metabolic Regulators: Extending Lifespan by Modulating Energy Production and Mitigating Cell Damage
Contents Rapamycin Rapamycin’s Modulation of Metabolism Rapamycin’s Lifespan Extension Urolithin A Urolithin A Improves Mitochondria to Enhance Metabolism Acarbose Acarbose as a Metabolic Modulator Acarbose’s Longevity Extension Effects Glycine and N-Acetyl Cysteine GlyNAC Modulates Metabolism GlyNAC’s Influence on Longevity Canagliflozin Canagliflozin Enhances Metabolism Canagliflozin’s Longevity Influences Supplementing with Metabolic Regulators Metabolism is the sum of… Continue reading Metabolic Regulators: Extending Lifespan by Modulating Energy Production and Mitigating Cell Damage
David Sinclair’s Claims Over New “Age-Reversal” Study Prompts Criticism by Fellow Biologists
Key Points: Undoubtedly, Harvard Professor Dr. David Sinclair’s work has contributed to the ever-evolving field of aging biology. One thing’s for sure, he’s helped popularize the notion that aging can be reversed with a pill. However, it’s this very claim that has gotten him into trouble with other biologists. On July 12th, 2023, Sinclair shared… Continue reading David Sinclair’s Claims Over New “Age-Reversal” Study Prompts Criticism by Fellow Biologists
Manipulating Aging through Cutting-Edge Gene Therapies
Contents History of Gene Therapy Gene Therapy Strategies Targeted Genes for Gene Therapy Telomerase Gene APOE KLOTHO FOXOs SIRT VEGF Safety Concerns for Gene Therapy Make Future Research Essential The natural process of aging engenders physiological decline, including the precipitation of age-related cardiovascular, metabolic, and neurodegenerative conditions, along with cancer. Since many age-related diseases stem… Continue reading Manipulating Aging through Cutting-Edge Gene Therapies
Sirtuin Modulating Compounds: Influencing the Function of Key Proteins for Longevity
Contents Introduction: Explaining Sirutins Targeting Sirtuins for Different Age-Related Conditions SIRT-1 Modulators Sirt-1 Activation Synthetic Sirtuin Activators Naturally-Occurring SIRT-1 Activators Other Sirtuin modulators Choosing a Sirtuin Modulator for Use Sirtuins are a family of enzymes that depend on the molecule nicotinamide adenine dinucleotide (NAD+) for their function. In mammals, there are seven known sirtuins named… Continue reading Sirtuin Modulating Compounds: Influencing the Function of Key Proteins for Longevity
NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels
Contents What Does NAD+ Do? Effects of Restoring NAD+ with Its Precursors NAD+ Precursor Clinical Trials NMN NR Nicotinamide Niacin Tryptophan Choosing and Obtaining NAD+ Precursors The reduction of nicotinamide adenine dinucleotide (NAD+) with age leads to declining cellular energy production and increases inflammation. These factors lead to accelerated aging and an increased incidence of… Continue reading NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels
Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization
Contents Introduction: What are senolytics? Examples of senolytics and their current data Active and Planned Senolytic Human Trials Commercially available senolytics As we grow older, the number of aged, non-proliferative senescent cells that release a milieu of inflammatory molecules to surrounding cells increases throughout our bodies. The molecule combination that senescent cells release (the senescence-associated… Continue reading Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization
Harnessing Stem Cells to Fight Aging
Contents Stem Cells Have the Capacity to Develop into Multiple Tissue Cell Types Seven Stem Cell Subtypes Countering Different Age-Related Conditions Adult Stem Cells Are Easier to Obtain Stem Cells’ Therapeutic Effects Come from Vesicle Signaling The World Health Organization estimates that the global population over age 60 will reach 2 billion by 2050. With… Continue reading Harnessing Stem Cells to Fight Aging
Is Aging a Software Design Flaw? A Fresh Perspective on the Science of Aging
Key Points: Despite its inevitable reality, at the biological level, aging remains poorly understood. Many theories suppose that aging is caused by the accumulation of damage over time. That is, damage to the “hardware,” including DNA, cells, and organs. However, Dr. João Pedro de Magalhães from the University of Birmingham in the U.K. argues in … Continue reading Is Aging a Software Design Flaw? A Fresh Perspective on the Science of Aging
The Hallmarks of Aging and How To Target Them
Key Points: In 2013, an international group of researchers published nine hallmarks of aging based on the latest aging biology research. Since then, new discoveries have mounted, prompting the group to add five new hallmarks, published in Cell. Each hallmark is a time-dependent manifestation that parallels chronological aging and can be experimentally accelerated but potentially… Continue reading The Hallmarks of Aging and How To Target Them