Key Points NMN is an acronym for nicotinamide mononucleotide, a molecule that’s found naturally in all life forms. NMN serves as a precursor to an essential molecule for cell energy generation, DNA repair, and harmful oxygen-containing molecule (reactive oxygen species) disposal – NAD+. As such, supplementing with NMN has been found to significantly increase blood… Continue reading What Exactly is NMN? | Nicotinamide Mononucleotide
Category: Reviews
Sirtuins, NAD⁺, Lifespan Extension, and Aging
Key Points: The human body is multifaceted and complex, housing a myriad of unique molecules that regulate homeostasis and promote survival. From our diverse pool of cellular health regulators, a family of seven enzymes called sirtuins has emerged as key proteins intricately linked to biological processes that affect metabolism, aging, and longevity. Namely, evidence indicates… Continue reading Sirtuins, NAD⁺, Lifespan Extension, and Aging
What Are Senolytics?
Key Points As we get older, the number of aged, non-proliferating senescent cells that release a milieu of inflammatory molecules to surrounding cells increases throughout our bodies. The combination of molecules that senescent cells release (the senescence-associated secretory phenotype [SASP]) also induces healthy cells that come into contact with them to become senescent. Although many… Continue reading What Are Senolytics?
Scientist Challenges David Sinclair’s Best-Selling Book on Aging
Key Points: In a letter to the editor published in Archives of Gerontology and Geriatrics, Charles Brenner, a chairman at the City of Hope National Medical Center who helped popularize nicotinamide riboside as a NAD+ precursor, reviews David Sinclair’s book Lifespan. “Lifespan … represents a pivot in which a person central to the failure of… Continue reading Scientist Challenges David Sinclair’s Best-Selling Book on Aging
NAD⁺ Precursors and Aging
Key Points: Within each of our cells, a small molecule called nicotinamide adenine dinucleotide (NAD+) mediates the biochemical reactions necessary for our survival. However, this essential molecule declines with age. Age-related NAD+ depletion has been observed in the muscle, liver, fat, brain, pancreas, spleen, heart, kidney, and lung tissue of rodents and the skin, brain, liver, and blood… Continue reading NAD⁺ Precursors and Aging