Key Points: In 2013, an international group of researchers published nine hallmarks of aging based on the latest aging biology research. Since then, new discoveries have mounted, prompting the group to add five new hallmarks, published in Cell. Each hallmark is a time-dependent manifestation that parallels chronological aging and can be experimentally accelerated but potentially… Continue reading The Hallmarks of Aging and How To Target Them
Category: Reviews
What Exactly is NMN? | Nicotinamide Mononucleotide
Key Points NMN is an acronym for nicotinamide mononucleotide, a molecule that’s found naturally in all life forms. NMN serves as a precursor to an essential molecule for cell energy generation, DNA repair, and harmful oxygen-containing molecule (reactive oxygen species) disposal – NAD+. As such, supplementing with NMN has been found to significantly increase blood… Continue reading What Exactly is NMN? | Nicotinamide Mononucleotide
Sirtuins, NAD⁺, Lifespan Extension, and Aging
Key Points: The human body is multifaceted and complex, housing a myriad of unique molecules that regulate homeostasis and promote survival. From our diverse pool of cellular health regulators, a family of seven enzymes called sirtuins has emerged as key proteins intricately linked to biological processes that affect metabolism, aging, and longevity. Namely, evidence indicates… Continue reading Sirtuins, NAD⁺, Lifespan Extension, and Aging
What Are Senolytics?
Key Points As we get older, the number of aged, non-proliferating senescent cells that release a milieu of inflammatory molecules to surrounding cells increases throughout our bodies. The combination of molecules that senescent cells release (the senescence-associated secretory phenotype [SASP]) also induces healthy cells that come into contact with them to become senescent. Although many… Continue reading What Are Senolytics?
Scientist Challenges David Sinclair’s Best-Selling Book on Aging
Key Points: In a letter to the editor published in Archives of Gerontology and Geriatrics, Charles Brenner, a chairman at the City of Hope National Medical Center who helped popularize nicotinamide riboside as a NAD+ precursor, reviews David Sinclair’s book Lifespan. “Lifespan … represents a pivot in which a person central to the failure of… Continue reading Scientist Challenges David Sinclair’s Best-Selling Book on Aging
NAD⁺ Precursors and Aging
Key Points: Within each of our cells, a small molecule called nicotinamide adenine dinucleotide (NAD+) mediates the biochemical reactions necessary for our survival. However, this essential molecule declines with age. Age-related NAD+ depletion has been observed in the muscle, liver, fat, brain, pancreas, spleen, heart, kidney, and lung tissue of rodents and the skin, brain, liver, and blood… Continue reading NAD⁺ Precursors and Aging