Key Points: As published in Communications Medicine, Pike and colleagues from the University of Southern California in Los Angeles find that in genetically engineered mice with the human version of a DNA sequence predisposing to dementia and accelerated aging (APOE4), treating with alfatradiol improves scores on an assessment of age-related physical decline (frailty index score).… Continue reading USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s
Category: Aging & Longevity
Anti-Aging Drug Rapamycin Extends Life as Much as Dieting, New Study Shows
Key Points: The pursuit of living longer has moved from ancient myths to modern laboratories, where scientists are meticulously unraveling the complex biological processes of aging. Among the most promising avenues of research are dietary restriction (DR) and certain compounds that mimic its effects. A recent meta-analysis, a powerful research method that combines findings from… Continue reading Anti-Aging Drug Rapamycin Extends Life as Much as Dieting, New Study Shows
The UN’s Brief on the Biology of Aging
Key Points: Aging is an inevitable part of life, a complex process that affects every living organism. For centuries, humanity has been fascinated by the prospect of extending lifespan and maintaining vitality into old age. While the fountain of youth remains a mythical concept, groundbreaking scientific advancements are shedding new light on the biological mechanisms… Continue reading The UN’s Brief on the Biology of Aging
Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan
Key Points: Figuring out which molecular pathways scientists should target to promote longevity has gained momentum in the aging research field in the last two to three decades. For example, in 2003, Müller and colleagues from the University of Fribourg in Switzerland showed that inhibiting a protein that regulates cell growth and proliferation (mTOR) significantly… Continue reading Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan
Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age
Key Points: In a first-of-its-kind human study published in Aging Cell, Furman and colleagues from the Buck Institute for Research on Aging show that removing and replacing blood plasma with a fresh solution (therapeutic plasma exchange) confers about a 1.32-year reduction in biological age. Additionally, combining therapeutic plasma exchange with injections of a concentrated solution… Continue reading Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age
Longevity Secrets in Your Genome: Hidden mTOR Variants Identified
Key Points: In a new study published in GeroScience, German researchers have uncovered compelling evidence that a cellular pathway called mTOR, often described as the body’s “longevity switch,” may hold the key to understanding how we age and how to extend healthy lifespan. What Is the mTOR Pathway? The mechanistic target of rapamycin (mTOR) signaling… Continue reading Longevity Secrets in Your Genome: Hidden mTOR Variants Identified
Longevity Prescription
Proven longevity anti-aging drugs that extend lifespan. Lifestyle strategies, nutrition, sleep, exercise, and toxin avoidance, all in the one best and most comprehensive guide.
Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol
According to his website, Siim Land takes the following supplements daily: Siim Land, an Estonian author, biohacker, and content creator, has become a prominent voice in the world of health, performance, and longevity. Many have wondered about his age, and when asked by aging expert Matt Kaeberlein, Siim revealed that he is 30 (despite looking… Continue reading Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol
Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study
Key Points: As published in the Journal of Advanced Research, Jung and colleagues from the Korea University of Science and Technology showed that niclosamide alleviated frailty and prevented the loss of endurance and strength in old mice. Moreover, in muscle cells, niclosamide reduced factors linked to the hyperactivation of mTOR, which researchers have tied to… Continue reading Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study
New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates
Key Points: A new pre-print (not yet peer-reviewed) paper challenges the current consensus on the genetic contribution to human lifespan. While previous studies estimated heritability at 15-33% (typically 20-25%), with some suggesting it could be as low as 7%, this study demonstrates that when confounding factors are properly addressed, the intrinsic heritability of human lifespan… Continue reading New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates