Key Points: A new pre-print (not yet peer-reviewed) paper challenges the current consensus on the genetic contribution to human lifespan. While previous studies estimated heritability at 15-33% (typically 20-25%), with some suggesting it could be as low as 7%, this study demonstrates that when confounding factors are properly addressed, the intrinsic heritability of human lifespan… Continue reading New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates
Category: Aging & Longevity
Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors
Key Points: Aging interventions based on increasing the cellular molecule nicotinamide adenine dinucleotide (NAD+), essential for life-sustaining reactions, have evolved substantially over the years. For starters, researchers’ understanding of NAD+ began with recognizing its crucial role in metabolism and that its cellular levels decline with age across multiple species, including humans. NAD+ research has subsequently… Continue reading Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors
Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So
Key Points: The intestines serve as a vital component of the digestive system, with critical functions in digestion and nutrient absorption. They also work as a barrier between the gut and the circulatory system, preventing harmful substances and bacteria from entering the blood and, ultimately, the organs. Degenerative changes to the intestines with age lead… Continue reading Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So
Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025
Key Points: Aging guru and venture capitalist Bryan Johnson asked a groundbreaking question about three years ago: Will his generation be the first that does not die? To address this question, Johnson hired a team of 30 medical professionals to measure the biological age—an age assessment based on tissue and organ function—of each of his… Continue reading Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025
One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows
Key Points: The anti-aging molecule klotho has gained the attention of researchers exploring the limits of gene therapy — a technique that modifies a person’s genes — and delaying cellular aging. To do so, Roig-Soriano and colleagues injected the klotho gene into mice. They injected mice that were 6 months old, roughly equivalent to a 31-year-old human,… Continue reading One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows
Common Diabetes Medication Might Extend Life, Suggests New Study
Key Points: Dysfunction of the cell’s powerhouse—mitochondria—is a hallmark of aging and has been tied to age-related neurodegenerative disorders, cardiovascular disease, and metabolic conditions. Interestingly, the diabetes drug chlorpropamide has been shown to exert effects against aging in worms by altering mitochondrial function. This finding has drawn attention to the class of diabetes medications to… Continue reading Common Diabetes Medication Might Extend Life, Suggests New Study
Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics
Key Points: Published in the Journals of Gerontology, 60 aging research experts from various international institutions, including the University of Pennsylvania and the Germany-based Max Planck Insitute for Biology and Ageing, arrived at a consensus to designate markers of aging—referred to as biomarkers. These aging markers included some related to physiological function, inflammation, physical function,… Continue reading Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics
Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals
Key Points: Aging is a relentless biological process that affects every tissue in the body, and our joints are no exception. Osteoarthritis (OA), a degenerative joint disorder, affects millions worldwide and is exacerbated by both aging and surgical trauma. While traditional treatments focus on managing pain and inflammation, emerging research suggests that metabolic interventions may… Continue reading Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals
Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging
Key Points: There’s a reason why you keep hearing about omega-3s, the healthy fats found in fish, such as salmon and sardines. Omega-3 supplements are everywhere, always on the shelves of grocery and vitamin stores. Why? Because you basically need them for your brain to function optimally, both cognitively and emotionally. Not to mention that… Continue reading Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging
New Age-Reversal Therapy Prolongs Life by Targeting Senescent Cells
Key Points: Mayo Clinic’s conceptual framework for treating the most deadly age-related diseases, including cancer and cardiovascular disease, involves targeting a single shared biological factor — senescent cells. Until now, the most well-established way of reducing senescent cells has been senolytics — compounds that selectively eliminate senescent cells. However, challenging the dogma that senescent cells are… Continue reading New Age-Reversal Therapy Prolongs Life by Targeting Senescent Cells