Key Points: Researchers from the University of Florida Health Cancer Center, Hackensack University Medical Center, and Weill Cornell Medicine identified a developmental molecule called Netrin-1 as a critical regulator of bone marrow cell aging. Co-lead authors Ramalingam, Gutkin, and Poulos demonstrate that supplementation of aged mice with Netrin-1 rejuvenates aged bone marrow and restores the… Continue reading Researchers Rejuvenate Aged Mouse Blood Stem Cells
Category: DNA Repair
Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA
Key Points: In fruit flies, rapamycin-induced improvements in gut health, and slightly increased lifespan are due to increased histones – proteins that help maintain the compact organization of DNA in the cell nucleus. Rapamycin also increases histone levels and reorganizes DNA in the small intestines of mice. We are made of cells, most of which… Continue reading Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA
What Are Telomeres? | Why Are They Important in Aging?
Telomeres are the protective endcaps of our chromosomes. They are made up of DNA and proteins, and they protect our genetic information from damage. Each time a cell divides, telomeres shorten a little bit. When they get too short, the cell can no longer divide, and it dies. Telomeres are therefore a marker of cellular… Continue reading What Are Telomeres? | Why Are They Important in Aging?
Humans Treated with Pressurized Oxygen Show Signs of Reversed Aging
Two major biological events associated to the onset of medical conditions that proceed upon aging are telomere shortening and the accumulation of senescent cells in the body. Telomeres encompass the regions at the ends of chromosomes and exhibit protective properties. Senescent cells are old cells that can no longer undergo cell division, and they ultimately… Continue reading Humans Treated with Pressurized Oxygen Show Signs of Reversed Aging
Supplementing with Nicotinamide Protects Skin Cells From UV-Induced DNA Damage
While many people are fond of being under the sun, they are still aware of the deleterious sun rays that are known to damage the skin. Exposure to ultraviolet (UV) radiation can ultimately lead to cell death by directly damaging DNA, inducing the production of cell hampering molecules known as reactive oxygen species, initiating local… Continue reading Supplementing with Nicotinamide Protects Skin Cells From UV-Induced DNA Damage
Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
Repetitive DNA strands called telomeres stop chromosome ends from fraying or sticking to each other, similar to plastic tips at the ends of shoelaces. These protective ends also ensure DNA gets copied correctly during cell replication. The length of telomeres is closely linked to aging, and when telomere length gets whittled down, cells age faster.… Continue reading Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends