Key Points: Figuring out which molecular pathways scientists should target to promote longevity has gained momentum in the aging research field in the last two to three decades. For example, in 2003, Müller and colleagues from the University of Fribourg in Switzerland showed that inhibiting a protein that regulates cell growth and proliferation (mTOR) significantly… Continue reading Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan
Category: Aging & Longevity
Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age
Key Points: In a first-of-its-kind human study published in Aging Cell, Furman and colleagues from the Buck Institute for Research on Aging show that removing and replacing blood plasma with a fresh solution (therapeutic plasma exchange) confers about a 1.32-year reduction in biological age. Additionally, combining therapeutic plasma exchange with injections of a concentrated solution… Continue reading Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age
Longevity Secrets in Your Genome: Hidden mTOR Variants Identified
Key Points: In a new study published in GeroScience, German researchers have uncovered compelling evidence that a cellular pathway called mTOR, often described as the body’s “longevity switch,” may hold the key to understanding how we age and how to extend healthy lifespan. What Is the mTOR Pathway? The mechanistic target of rapamycin (mTOR) signaling… Continue reading Longevity Secrets in Your Genome: Hidden mTOR Variants Identified
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Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol
According to his website, Siim Land takes the following supplements daily: Siim Land, an Estonian author, biohacker, and content creator, has become a prominent voice in the world of health, performance, and longevity. Many have wondered about his age, and when asked by aging expert Matt Kaeberlein, Siim revealed that he is 30 (despite looking… Continue reading Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol
Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study
Key Points: As published in the Journal of Advanced Research, Jung and colleagues from the Korea University of Science and Technology showed that niclosamide alleviated frailty and prevented the loss of endurance and strength in old mice. Moreover, in muscle cells, niclosamide reduced factors linked to the hyperactivation of mTOR, which researchers have tied to… Continue reading Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study
New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates
Key Points: A new pre-print (not yet peer-reviewed) paper challenges the current consensus on the genetic contribution to human lifespan. While previous studies estimated heritability at 15-33% (typically 20-25%), with some suggesting it could be as low as 7%, this study demonstrates that when confounding factors are properly addressed, the intrinsic heritability of human lifespan… Continue reading New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates
Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors
Key Points: Aging interventions based on increasing the cellular molecule nicotinamide adenine dinucleotide (NAD+), essential for life-sustaining reactions, have evolved substantially over the years. For starters, researchers’ understanding of NAD+ began with recognizing its crucial role in metabolism and that its cellular levels decline with age across multiple species, including humans. NAD+ research has subsequently… Continue reading Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors
Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So
Key Points: The intestines serve as a vital component of the digestive system, with critical functions in digestion and nutrient absorption. They also work as a barrier between the gut and the circulatory system, preventing harmful substances and bacteria from entering the blood and, ultimately, the organs. Degenerative changes to the intestines with age lead… Continue reading Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So
Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025
Key Points: Aging guru and venture capitalist Bryan Johnson asked a groundbreaking question about three years ago: Will his generation be the first that does not die? To address this question, Johnson hired a team of 30 medical professionals to measure the biological age—an age assessment based on tissue and organ function—of each of his… Continue reading Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025