Highlights: The molecule DSRM-3716 stops SARM1 from breaking down NAD+. Blocking SARM1 changes the fate of axon degeneration. SARM1 inhibitors have the potential to treat many neurodegenerative diseases. When a nerve fiber is cut or crushed, the projection withers away starting from the tip and back to the cell body. This process occurs in many… Continue reading Eli Lilly & Company’s Small Molecule Prevents Neurodegeneration
Category: Brain & Neurons
Spermidine Improves Brain Inflammation and Anxiety
Highlights Long-term spermidine treatment does not extend lifespan in rats. Spermidine improves anxiety and inflammation in aged rats. Cell recycling processes (autophagy) are activated with spermidine treatment. In the early 2000s, scientists coined the term inflammaging to describe the close relationship between low-grade chronic inflammation and aging. Inflammaging has been linked to a broad spectrum… Continue reading Spermidine Improves Brain Inflammation and Anxiety
Fisetin Alleviates Cognitive Dysfunction and Brain Inflammation
Highlights: Although evolution has trained our body’s internal soldiers — white blood cells — to fight off infection effectively with all its got, one particular condition known as sepsis piggybacks off our cellular defense mechanisms to target the whole body. When our bodies are introduced to foreign invaders, cells carefully trigger an inflammatory response. But… Continue reading Fisetin Alleviates Cognitive Dysfunction and Brain Inflammation
Omega-3 Improves Memory Deficits From Processed Diet
Highlights: Aged rats that consume a diet high in processed foods for 28 days exhibit cognitive deficits in brain regions linked to memory. Proinflammatory genes display greater activation in aged rats fed a processed diet. DHA mitigates memory impairments and lowers proinflammatory gene expression in aged rats fed a processed diet. In grocery stores and… Continue reading Omega-3 Improves Memory Deficits From Processed Diet
Study Links Depression to Reduced Levels of NAD⁺-Producing Protein
Highlights: Researchers measured brain cell proteins from the blood of patients to identify psychiatric condition markers and therapeutic targets. Levels of the NAD+ generating protein NMNAT2 are disrupted in patients with Major Depressive Disorder (MDD). Since NAD+ levels also fall as biological age progresses, these findings provide a link between MDD and aging. Most of… Continue reading Study Links Depression to Reduced Levels of NAD⁺-Producing Protein
Resveratrol Restores Cognition (In Mice with Alzheimer’s)
Over the last few years, overconsumption of calories that derive from saturated fat has been a catalyst to the progression of global obesity, and metabolic and brain disorders have also been linked to caloric overconsumption. Mouse and human models have provided overwhelming evidence that Alzheimer’s disease, along with other manifestations of cognitive impairment, can be… Continue reading Resveratrol Restores Cognition (In Mice with Alzheimer’s)
NAD+ Allays Multiple Sclerosis in Mice
Multiple sclerosis is a seriously disabling disease involving our immune system’s attack on healthy cells. This self-inflicted response progressively causes nervous system inflammation and the stripping of protective fats coating nerve projections (demyelination). Figuring out how to suppress this nervous system inflammation and keep nerves healthy would be an attractive therapeutic strategy. Wang and colleagues… Continue reading NAD+ Allays Multiple Sclerosis in Mice
Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Several age-related studies seek to understand how gene regulation is affected by methyl groups, which are compounds known to attach to DNA via a process called methylation. Decreases in gene activation are associated with increases in methylation. As humans age, methylation patterns diverge, and cells end up reading incorrect genes, promoting age-related diseases and malfunctional… Continue reading Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Drug Rejuvenates Neuron Function and Cognition in Aged Mice
As the global population continues to age and grow in number, age-related cognitive impairment has progressively become a pressing issue. A deleterious neurological mechanism called the integrated stress response (ISR) becomes apparent as humans age and promotes age-associated cognitive impairment. In a study published on December 1st (year) in the open-access journal eLife, Rosi and… Continue reading Drug Rejuvenates Neuron Function and Cognition in Aged Mice
Lilly Lands Disarm Therapeutics and NAD⁺ Metabolism Drug to Fight Neurological Diseases
Neurodegeneration is a prevalent yet unaddressed symptom of a wide range of neurological illnesses that can impair many of your body’s functions, including talking, breathing, balance, movement, and heart function. However, there are currently no effective therapeutics because clinical trials for neuroprotective treatments that address neurodegenerative disorders have failed. The pharmaceutical company Eli Lilly and… Continue reading Lilly Lands Disarm Therapeutics and NAD⁺ Metabolism Drug to Fight Neurological Diseases