Over the last few years, overconsumption of calories that derive from saturated fat has been a catalyst to the progression of global obesity, and metabolic and brain disorders have also been linked to caloric overconsumption. Mouse and human models have provided overwhelming evidence that Alzheimer’s disease, along with other manifestations of cognitive impairment, can be… Continue reading Resveratrol Restores Cognition (In Mice with Alzheimer’s)
Category: Brain & Neurons
NAD+ Allays Multiple Sclerosis in Mice
Multiple sclerosis is a seriously disabling disease involving our immune system’s attack on healthy cells. This self-inflicted response progressively causes nervous system inflammation and the stripping of protective fats coating nerve projections (demyelination). Figuring out how to suppress this nervous system inflammation and keep nerves healthy would be an attractive therapeutic strategy. Wang and colleagues… Continue reading NAD+ Allays Multiple Sclerosis in Mice
Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Several age-related studies seek to understand how gene regulation is affected by methyl groups, which are compounds known to attach to DNA via a process called methylation. Decreases in gene activation are associated with increases in methylation. As humans age, methylation patterns diverge, and cells end up reading incorrect genes, promoting age-related diseases and malfunctional… Continue reading Reversing Age-Related Vision Loss with Embryonic Gene Delivery
Drug Rejuvenates Neuron Function and Cognition in Aged Mice
As the global population continues to age and grow in number, age-related cognitive impairment has progressively become a pressing issue. A deleterious neurological mechanism called the integrated stress response (ISR) becomes apparent as humans age and promotes age-associated cognitive impairment. In a study published on December 1st (year) in the open-access journal eLife, Rosi and… Continue reading Drug Rejuvenates Neuron Function and Cognition in Aged Mice
Lilly Lands Disarm Therapeutics and NAD⁺ Metabolism Drug to Fight Neurological Diseases
Neurodegeneration is a prevalent yet unaddressed symptom of a wide range of neurological illnesses that can impair many of your body’s functions, including talking, breathing, balance, movement, and heart function. However, there are currently no effective therapeutics because clinical trials for neuroprotective treatments that address neurodegenerative disorders have failed. The pharmaceutical company Eli Lilly and… Continue reading Lilly Lands Disarm Therapeutics and NAD⁺ Metabolism Drug to Fight Neurological Diseases
NAD⁺ Binds to and Inhibits a Neuron Degeneration-Promoting Protein
Degeneration of axons, which transmit signals from one neuron to another, occurs in neurological diseases. A molecule called nicotinamide adenine dinucleotide (NAD+) has a critical role in axon maintenance through unclear influences on a protein called Sarm1 that when activated causes neuron degeneration, the progressive atrophy and loss neuron function. Scientists from Peking University in… Continue reading NAD⁺ Binds to and Inhibits a Neuron Degeneration-Promoting Protein
Gold Nanocrystal from Clene Nanomedicine Improves NAD⁺ Levels in Multiple Sclerosis and Parkinson’s Disease Patients
Multiple sclerosis is an inflammatory, demyelinating condition of the central nervous system that is the most prevalent inducer of neurological impairment in young adults, affecting almost one million people in the United States. In addition, approximately one-third of individuals with multiple sclerosis develop relapse multiple sclerosis, a progressive form of the illness for which there… Continue reading Gold Nanocrystal from Clene Nanomedicine Improves NAD⁺ Levels in Multiple Sclerosis and Parkinson’s Disease Patients
Increasing Lifespan of Leigh Syndrome Mice with NAD⁺ Level Restoration
Mitochondria are unique structures present in all cells that are essential to producing energy and stimulating growth. Malfunctional mitochondria can promote the development of degenerative brain conditions, such as Parkinson’s disease and Leigh syndrome, a dreadful neurological disorder that leads to progressive decreases in mental and movement capabilities that typically result in childhood mortalities. Unraveling… Continue reading Increasing Lifespan of Leigh Syndrome Mice with NAD⁺ Level Restoration
Manipulating NAD⁺ Levels Has Potential Therapeutic Role for Neural Damage
Traumatic brain injuries and disorders of the brain, such as Alzheimer’s disease and Parkinson’s disease, induce neuronal damage. Neuronal damage induced by injuries and diseases can become present in the short-term right after the occurrence, or it can develop chronically over time. Researchers investigate brain injuries and diseases utilizing different animal models with the ambition… Continue reading Manipulating NAD⁺ Levels Has Potential Therapeutic Role for Neural Damage
Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer
Uncontrollably growing cells can form tumors, and when tumors form, they are confronted and invaded by the body’s defense–the immune system. Yet tumors often disarm our protective immune cells, which renders them ineffective and eliminates their cancer cell killing capabilities. This is true for the deadly and highly incurable brain cancer called glioblastoma. So, finding… Continue reading Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer