Key Points: While many of us, including pharmaceutical companies, hope that AD can be cured with therapeutic drugs, a new study from the University of Southern California (USC) suggest that such drugs may be unnecessary. Published in Cell Reports, Rangan and colleagues show that FMD reduces brain inflammation and cognitive decline in a mouse model… Continue reading USC Scientists Reveal that Fasting-Mimicking Diet Reduces Brain Pathology and Cognitive Decline in Alzheimer’s
Category: Brain & Neurons
Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Key Points: Aging is multifaceted and complex, involving a myriad of interacting biological pathways that gradually collapse and lead to organ and tissue dysfunction. Many of the current anti-aging therapeutics target only one specific biological pathway, narrowing their impact on slowing, preventing, or reversing aging. This is why scientists have turned to drug combinations that… Continue reading Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Dublin Scientists Develop Gene Therapy for Eye Degeneration
Key Points: A gene called NDI1 is delivered to mouse and human cell models for age-related macular degeneration (AMD) as therapy. NDI1 therapy reduces molecules called reactive oxygen species (ROS) while raising nicotinamide adenine dinucleotide (NAD+) levels. Treatment with NDI1 recovers the function of mitochondria — key modulators of cell health and aging. To visualize… Continue reading Dublin Scientists Develop Gene Therapy for Eye Degeneration
Korean Study Shows Vitamin B₃ Alleviates Diabetes-Induced Eye Degeneration
Key Points: Vitamin B3 (nicotinamide) treatment reduces cell death and injury in the retinas of rats modeling diabetes. Treatment with nicotinamide enhances DNA repair in the retinas of diabetic rats. Among the myriad of risks associated with diabetes, one that severely impacts life quality is blindness, which stems from the deterioration of the retina –… Continue reading Korean Study Shows Vitamin B₃ Alleviates Diabetes-Induced Eye Degeneration
Japan Study Shows Pearl Extract Rejuvenates Aged Brain and Skin
Key Points: Treatment with pearl extract improves memory deficits in aged mice by preventing neurodegeneration. Pearl extract rejuvenates the fur of aged mice while reversing aspects of skin aging, such as thinning and wrinkles. Rejuvenation is attributed to elevated antioxidants and reduced cellular stress. Pearls are often associated with a vintage look and grandmotherly vibe.… Continue reading Japan Study Shows Pearl Extract Rejuvenates Aged Brain and Skin
Falsified Data Could Set Alzheimer’s Research Back 16 Years
Key Points: Dozens of potentially doctored images were found in scientific publications that laid the groundwork for current theories of Alzheimer’s disease (AD) progression. Therapies based on these theories have failed in clinical trials, leading to questions regarding these initial claims. For a long-time now, over a decade, it’s been thought that researchers were on… Continue reading Falsified Data Could Set Alzheimer’s Research Back 16 Years
Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models
Key Points: Our cells utilize hundreds of enzymes to operate on a daily basis, yet few are well-renowned for their lifespan-extending and anti-aging effects as sirtuins. Considering that disorders like Parkinson’s and Alzheimer’s disease are a consequence of aging, enhancing the activity of sirtuin enzymes may provide a key to treating these incurable diseases. In… Continue reading Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models
UTHealth Researchers Show Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk
Key Points: 8.5% of unvaccinated older adults developed Alzheimer’s after four years, while 5.1% developed the disease if vaccinated. Regular annual flu vaccinations are predicted to reduce Alzheimer’s disease incidence further. In the past few years, the topic of flu vaccinations has been fairly polarizing, with many of the general public indicating that the flu… Continue reading UTHealth Researchers Show Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk
Study Finds Fat Molecules that Improve Age-Related Cognitive Deficits
Key Points: Treatment with plasmalogens improves the learning and memory of aged mice. Aged mice treated with plasmalogens have a healthier appearance with glossier fur. Plasmolgens promote the generation of new neurons while reducing inflammation. The connections between the neurons in our brain begin to dwindle as we age, leading to cognitive deficits such as… Continue reading Study Finds Fat Molecules that Improve Age-Related Cognitive Deficits
Gum Disease Pathogen Fusobacterium nucleatum May Increase Alzheimer’s Risk
Key Points: The gum disease-assocaited bacteria F. nucleatum lowers cognitive function in mice. The brain tissue of mice with gum disease exhibit significantly higher levels of amyloid beta (Aβ) and phosphorylated-tau (p-Tau), both hallmarks of Alzheimer’s disease progression. Mice with gum disease also have elevated brain inflammation. The CDC confirms that nearly 50% of adults… Continue reading Gum Disease Pathogen Fusobacterium nucleatum May Increase Alzheimer’s Risk