Key Points: Suppressing CD38 raises NAD+ levels and enhances exercise performance in mice. CD38 suppression also improves heart rate and heart rate variability. Deletion of CD38 protects mice against heart rhythm abnormalities. As long as we are alive, the heart never ceases to beat. With each pump, billions of metabolically active, energy-consuming cells orchestrate the… Continue reading Scientists find that Suppressing NAD⁺ Degradation Improves Exercise Performance and Prevents Abnormal Heart Rhythms in Mice
Category: Cardiovascular
UPenn Researchers Engineer Immune Cells that Restore Heart Function
Key Points: When our hearts succumb to injury, our cells kick into high gear and activate cells that make up our connective tissue (fibroblasts), generating fibrous scar tissue in a process known as fibrosis. However, the continual accumulation of fibrous scar tissue rigifies the heart muscle, diminishing overall performance and contributing to the development of… Continue reading UPenn Researchers Engineer Immune Cells that Restore Heart Function
Rodent Study Shows NMN Protects the Heart from Chemotherapy Toxicity
Highlights Toxic effects on heart cells caused by doxorubicin — a common chemotherapy drug — were reversed with NMN treatment. NMN prevents inflammation, oxidative stress, and heart cell death induced by doxorubicin, restoring heart function. These findings contribute to the idea of using NMN as an adjuvant to chemotherapeutics. Cancer treatment requires the delicate calibration… Continue reading Rodent Study Shows NMN Protects the Heart from Chemotherapy Toxicity
Preliminary Clinical Trial Data Shows NAD⁺ Improves Inflammatory Response in Heart Failure
Although the immune system utilizes inflammation as a method to restore health in the body, there is evidence suggesting that inflammation may be linked to progressive heart failure. Immune cells that facilitate this process highly rely on the mitochondria, the powerhouse of the cell, to provide energy. However, researchers still don’t know whether malfunctional mitochondria… Continue reading Preliminary Clinical Trial Data Shows NAD⁺ Improves Inflammatory Response in Heart Failure
The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation
Aging and obesity increase the risk of humans developing onset atrial fibrillation, a condition where the upper (atria) and lower (ventricles) chambers of the heart have unsynchronized beating rhythms. Atrial fibrillation is the most prevalent issue pertaining to the rate or rhythm of the heartbeat, and it is known to affect over 33 million people… Continue reading The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation