Key Points: Human cells successfully repopulate a rabbit heart that has been decellularized – cleared of all (rabbit) cells. When blood is passed through the heart, it visibly pumps. The repopulated heart responds to medications that affect heart rate. Heart attacks can be deadly or cause irreparable damage, especially with advanced age. This is due… Continue reading Scientists Recreate Functional Human Heart Tissue from Animal Scaffolding
Category: Cardiovascular
Study Shows Traditional Chinese Medicine Delays Cardiac Aging
Key Points: Treatment with THBru improves heart function, reduces fibrosis (scarring), and decreases senescent (aged) cells in a mouse model for aging. THBru delays cardiac aging by activating mitophagy – the clearance of defective/dead mitochondria. Removing damaged cellular components, such as defective mitochondria via mitophagy, is vital to thwarting energy depletion, oxidative stress, and inflammation,… Continue reading Study Shows Traditional Chinese Medicine Delays Cardiac Aging
Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Key Points: Aging is multifaceted and complex, involving a myriad of interacting biological pathways that gradually collapse and lead to organ and tissue dysfunction. Many of the current anti-aging therapeutics target only one specific biological pathway, narrowing their impact on slowing, preventing, or reversing aging. This is why scientists have turned to drug combinations that… Continue reading Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Large Study Finds Increased Risk of Heart Disease Linked to Napping
Key Points: Individuals who napped for over 30 minutes in the daytime were more likely to succumb to cardiovascular disease, hypertension (high blood pressure), or stroke. Daytime napping for over an hour leads to more profound effects than napping for just 30 minutes. Daytime sleeping (napping) is commonly thought to rejuvenate and promote healthy habits,… Continue reading Large Study Finds Increased Risk of Heart Disease Linked to Napping
New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
Key Points: Our genetic blueprints (DNA) are constantly being studied to identify longevity-linked genes and pathways that may hold the key to prolonging our lifespan. One particular gene that has strong ties to longevity is Cisd2. In addition to extending the lifespan of rodents through increased activity, activation of Cisd2 protects against cardiac dysfunction and… Continue reading New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
Study Finds Berberine Protects Against Cardiac Aging by Regulating Anti-Aging Protein
Key Points: Berberine slows signs of aging in heart cells, including decreasing cellular senescence – a critical state where cells can no longer divide and multiply (proliferate). Many beneficial effects of berberine require klotho, an anti-aging protein associated with extending lifespan and mitigating age-related diseases. Old rats treated with berberine exhibit less cardiac fibrosis –… Continue reading Study Finds Berberine Protects Against Cardiac Aging by Regulating Anti-Aging Protein
NR Reduces Stroke-Induced Brain Damage, Study Finds
Key Points: When our arteries are blocked, the life-sustaining oxygen and nutrients within our blood cannot reach our cells, leading quickly to cellular energy reductions and cell death. This blocking of the arteries and lack of blood flow that often occurs with aging is called an ischemic stroke and if it occurs in the hippocampus… Continue reading NR Reduces Stroke-Induced Brain Damage, Study Finds
Study Shows Low NAD⁺ Associated with Increased Rates of Anemia
Key Points: Anemia among middle-aged women is associated with decreased NAD+ levels. Health-related blood factors – including red blood cell counts and hemoglobin – are positively associated with NAD+ levels. When it comes to aging, NAD+ and anemia have a complicated relationship. NAD+ is a molecule essential for numerous cellular processes and is largely considered… Continue reading Study Shows Low NAD⁺ Associated with Increased Rates of Anemia
Study Shows JUUL E-Cigarettes Increase Inflammatory Gene Activity in the Brain and Heart of Mice
Key Points: Mice exposed to JUUL aerosols displayed evidence of brain inflammation (neuroinflammation). Mice with pulmonary (lung) injury exhibit cardiac inflammation following JUUL exposure. The inflammatory profile in response to JUUL aerosols is different between Mint and Mango flavorants. Although current data is clear on the detrimental effects of long-term exposure to tobacco smoke, scientists… Continue reading Study Shows JUUL E-Cigarettes Increase Inflammatory Gene Activity in the Brain and Heart of Mice
Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy
Key Points: Deleting CD38 from mice restores heart function by correcting calcium homeostasis. Respiratory and muscle function are improved by deleting CD38. Inhibiting CD38 in human muscle cells corrects calcium homeostasis. Like buttress reinforcing the walls of a cathedral, there are proteins that reinforce the structure of our cells. When these proteins are compromised, cells… Continue reading Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy