Key Points: Aging is multifaceted and complex, involving a myriad of interacting biological pathways that gradually collapse and lead to organ and tissue dysfunction. Many of the current anti-aging therapeutics target only one specific biological pathway, narrowing their impact on slowing, preventing, or reversing aging. This is why scientists have turned to drug combinations that… Continue reading Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Category: Cardiovascular
Large Study Finds Increased Risk of Heart Disease Linked to Napping
Key Points: Individuals who napped for over 30 minutes in the daytime were more likely to succumb to cardiovascular disease, hypertension (high blood pressure), or stroke. Daytime napping for over an hour leads to more profound effects than napping for just 30 minutes. Daytime sleeping (napping) is commonly thought to rejuvenate and promote healthy habits,… Continue reading Large Study Finds Increased Risk of Heart Disease Linked to Napping
New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
Key Points: Our genetic blueprints (DNA) are constantly being studied to identify longevity-linked genes and pathways that may hold the key to prolonging our lifespan. One particular gene that has strong ties to longevity is Cisd2. In addition to extending the lifespan of rodents through increased activity, activation of Cisd2 protects against cardiac dysfunction and… Continue reading New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
Study Finds Berberine Protects Against Cardiac Aging by Regulating Anti-Aging Protein
Key Points: Berberine slows signs of aging in heart cells, including decreasing cellular senescence – a critical state where cells can no longer divide and multiply (proliferate). Many beneficial effects of berberine require klotho, an anti-aging protein associated with extending lifespan and mitigating age-related diseases. Old rats treated with berberine exhibit less cardiac fibrosis –… Continue reading Study Finds Berberine Protects Against Cardiac Aging by Regulating Anti-Aging Protein
NR Reduces Stroke-Induced Brain Damage, Study Finds
Key Points: When our arteries are blocked, the life-sustaining oxygen and nutrients within our blood cannot reach our cells, leading quickly to cellular energy reductions and cell death. This blocking of the arteries and lack of blood flow that often occurs with aging is called an ischemic stroke and if it occurs in the hippocampus… Continue reading NR Reduces Stroke-Induced Brain Damage, Study Finds
Study Shows Low NAD⁺ Associated with Increased Rates of Anemia
Key Points: Anemia among middle-aged women is associated with decreased NAD+ levels. Health-related blood factors – including red blood cell counts and hemoglobin – are positively associated with NAD+ levels. When it comes to aging, NAD+ and anemia have a complicated relationship. NAD+ is a molecule essential for numerous cellular processes and is largely considered… Continue reading Study Shows Low NAD⁺ Associated with Increased Rates of Anemia
Study Shows JUUL E-Cigarettes Increase Inflammatory Gene Activity in the Brain and Heart of Mice
Key Points: Mice exposed to JUUL aerosols displayed evidence of brain inflammation (neuroinflammation). Mice with pulmonary (lung) injury exhibit cardiac inflammation following JUUL exposure. The inflammatory profile in response to JUUL aerosols is different between Mint and Mango flavorants. Although current data is clear on the detrimental effects of long-term exposure to tobacco smoke, scientists… Continue reading Study Shows JUUL E-Cigarettes Increase Inflammatory Gene Activity in the Brain and Heart of Mice
Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy
Key Points: Deleting CD38 from mice restores heart function by correcting calcium homeostasis. Respiratory and muscle function are improved by deleting CD38. Inhibiting CD38 in human muscle cells corrects calcium homeostasis. Like buttress reinforcing the walls of a cathedral, there are proteins that reinforce the structure of our cells. When these proteins are compromised, cells… Continue reading Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy
Scientists find that Suppressing NAD⁺ Degradation Improves Exercise Performance and Prevents Abnormal Heart Rhythms in Mice
Key Points: Suppressing CD38 raises NAD+ levels and enhances exercise performance in mice. CD38 suppression also improves heart rate and heart rate variability. Deletion of CD38 protects mice against heart rhythm abnormalities. As long as we are alive, the heart never ceases to beat. With each pump, billions of metabolically active, energy-consuming cells orchestrate the… Continue reading Scientists find that Suppressing NAD⁺ Degradation Improves Exercise Performance and Prevents Abnormal Heart Rhythms in Mice
UPenn Researchers Engineer Immune Cells that Restore Heart Function
Key Points: When our hearts succumb to injury, our cells kick into high gear and activate cells that make up our connective tissue (fibroblasts), generating fibrous scar tissue in a process known as fibrosis. However, the continual accumulation of fibrous scar tissue rigifies the heart muscle, diminishing overall performance and contributing to the development of… Continue reading UPenn Researchers Engineer Immune Cells that Restore Heart Function