Key Points: Senile osteoporosis is an age-related condition in which the delicate balance between bone resorption (breakdown of bone for use by the body) and bone formation is skewed towards bone resorption leading to an increased risk of bone breakage. A recent study has shown how bone-targeted senolytics can help increase bone formation in this… Continue reading Study Finds Bone-Targeted Senolytics Decrease Age-related Osteoporosis
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Study Shows NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy
Key Points: While radiation therapy is highly effective at killing cancer cells, it inevitably causes damage to healthy tissues. When treating abdominal and pelvic cancer, intestinal injury is a typical side effect. This intestinal injury includes irreversible intestinal fibrosis (scarring), which can lead to other complications like mortality. Thus, there is an urgent need for… Continue reading Study Shows NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy
Scientists Develop Synthetic Stem Cells to Treat Arthritis
Key Points: Cell-free synthetic artificial stem cells (SASC) were developed to overcome problems associated with living stem cells. SASC reduces inflammation in a cell model for arthritis — a disease characterized by inflammation and degeneration of the joints. Degeneration and swelling of the knee joints are reduced by SASC in rats. It was once thought… Continue reading Scientists Develop Synthetic Stem Cells to Treat Arthritis
The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis
Key Points: The senolytic ABT-263 enhances the ability of mesenchymal stem cells (MSCs) to generate cartilage, the deterioration of which leads to arthritis. ABT-263 treatment eliminates senescent cells – non-proliferating cells linked to aging – from MSCs by inducing cell death (apoptosis). MSCs treated with ABT-263 grow into larger colonies, indicating a higher potential to… Continue reading The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis
An International Forum Provides Perspectives on Therapeutics for and Mechanisms of Aging
The proportion of aged people in the global population continues to rise, posing a number of health-related issues for societies relating to age-associated conditions. To attenuate these challenges, increasing research aimed at healthy aging and improved lifespan has revealed insight into longevity-related biological mechanisms that can be used to develop therapeutics to combat aging. The… Continue reading An International Forum Provides Perspectives on Therapeutics for and Mechanisms of Aging
Elysium Health™ Announces Phase II Trial for Preventing Acute Kidney Injury Following Heart Surgery with NAD⁺ Plus Antioxidant Supplement
A complication that frequently occurs in patients who undergo open cardiovascular repair or open-heart surgery is acute kidney injury, and evidence suggests that this condition is associated with diminished health- and lifespan. Unfortunately, the chances of hospital mortality, accruing health care costs, receiving long-term care, and developing chronic kidney disease are all increased in people… Continue reading Elysium Health™ Announces Phase II Trial for Preventing Acute Kidney Injury Following Heart Surgery with NAD⁺ Plus Antioxidant Supplement
How Does Space Travel Affect Natural Aging?
Growing older can take a serious toll on the body. Bones become brittle, muscle shrinks, the immune system loses strength, and age-related ailments like arthritis can set in. More serious complications like declining cognitive function and heart disease can also take hold as the later years of life progress. These symptoms can also come from… Continue reading How Does Space Travel Affect Natural Aging?
Challenges to the Validity of Patent for Nicotinamide Riboside Production
The presence of cellular nicotinamide adenine dinucleotide (NAD+), a compound critical for health and longevity, is known to decline as humans age. However, direct consumption of NAD+ lacks efficiency in restoring NAD+ within cells. Instead, a more effective method of boosting NAD+ involves utilizing precursor molecules of NAD+. Thus, there is widespread interest and competition… Continue reading Challenges to the Validity of Patent for Nicotinamide Riboside Production
Ancient Therapeutic Compound Improves Aged Muscle Energy Production
Muscle mass and strength in humans begin to decrease around age 40, and muscle mass is reduced by up to 50% when humans reach their 80s. Evidence suggests that these reductions in muscle mass and strength promote the development of sarcopenia, a syndrome that induces progressive decline of muscle and strength. Furthermore, this syndrome is… Continue reading Ancient Therapeutic Compound Improves Aged Muscle Energy Production
Researchers Pinpoint the Cause of a Disease that Leads to Childhood-Blindness
Onset through childhood and severe vision loss are characteristics of the degenerative disease known as Leber congenital amaurosis, which induces retina degeneration. Lately, mutations in NMNAT1, a crucial enzyme that helps facilitate the synthesis of nicotinamide adenine dinucleotide (NAD+), have been found in patients exhibiting Leber congenital amaurosis type 9. Thus, it is evident that… Continue reading Researchers Pinpoint the Cause of a Disease that Leads to Childhood-Blindness