When kidneys become damaged and can no longer filter blood properly, humans become susceptible to developing kidney disease. This has often been linked to malfunctional mitochondria, the cell’s power generator, and a reduction in the concentration of cellular nicotinamide adenine dinucleotide (NAD+), a vital compound that fuels functional mitochondria. However, there is no apparent connection… Continue reading NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term
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Insilico and Taisho Team Up to Make Anti-Aging Drugs with AI
Anti-aging drugs attempt to preserve or improve health and biological efficiency regardless of age. However, developing anti-aging drugs that are effective in humans has been difficult and elusive. Taisho Pharmaceutical Co., Ltd. of Japan and Insilico Medicine of Hong Kong have recently conducted collaborative research to discover novel anti-aging therapies. “It is believed that aging… Continue reading Insilico and Taisho Team Up to Make Anti-Aging Drugs with AI
Therapeutically Targeting Sirtuins Presents Promise for Lung Fibrosis
Lung fibrosis is the primary cause of death in industrialized societies and is one of the most feared pulmonary complications, with a clinically progressive yet unpredictable course. Early detection and timely prevention of this irreversible disease are the only available tools that resemble a cure; however, humans with progressive to advanced stages of this disease… Continue reading Therapeutically Targeting Sirtuins Presents Promise for Lung Fibrosis
Senolytics Prevent Inflammation and Bolster Aged Organ Survival Following Transplantation
In general, the solution to treat patients that exhibit end-stage organ failure is organ transplantation. While the supply and demand gap for organ transplantation is immense, there is potential in bridging this gap through the use of older organs. However, older organs tend not to be utilized in transplantation due to inducing elevated immune responses… Continue reading Senolytics Prevent Inflammation and Bolster Aged Organ Survival Following Transplantation
Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments
Chimeric antigen receptor (CAR) T cells, genetically altered immune cells extracted from patients and subsequently reintroduced, have obtained notoriety for treating blood malignancies. However, is it possible to utilize these cells to combat conditions like aging? In a study published in the journal Nature, Lowe and colleagues from Sloan Kettering Institute in New York demonstrated… Continue reading Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments
Challenges to the Current Thinking on Supplementing with NR
Many studies over the last few decades support the notion that declining function of the cell’s power-generating structure, the mitochondria, is linked with obesity, insulin resistance, and type 2 diabetes for rodent and human tissues. Studies have also shown metabolic impairments that come from diminished levels of a molecule called nicotinamide adenine dinucleotide (NAD+) that… Continue reading Challenges to the Current Thinking on Supplementing with NR
How to Improve Our Understanding of the Genetics of Human Aging
Aging takes place in many animals, and humans are no exception. But what does biological aging actually mean? Researchers describe aging as a reduction in the functional capabilities occurring over time and that typically begin once we become sexually mature. Changes affecting the function and activity of cells called biological hallmarks of aging cause deteriorating… Continue reading How to Improve Our Understanding of the Genetics of Human Aging