Key Points: Direct stimulation of muscle to measure strength is enhanced by rapamycin but not caloric restriction (CR). CR and rapamycin synergistically enhance grip strength and running distance in aged mice. Genes associated with muscle growth are increased by rapamycin but further decreased by CR. An often overlooked aspect of aging is a decline in… Continue reading Swiss Researchers find Rapamycin Prevents Age-Related Muscle Weakness
Category: Skin & Muscle
Study Shows Senolytics Restore Muscle Building Potential in Old Mice
Key Points: Old mice have high levels of senescent cells — zombie-like cells that accumulate with aging — and lack muscle growth in response to resistance exercise. Senolytics — compounds that kill senescent cells — restore muscle growth and diminish senescent cells in old mice. Senescent cells are present in human muscle after resistance exercise… Continue reading Study Shows Senolytics Restore Muscle Building Potential in Old Mice
Scientists Genetically Reprogram Human Skin Cells to be 30 Years Younger
Key Points: A new method of genetic reprogramming rejuvenates skin cells by 30 years, importantly, without losing their identity. Rejuvenated skin cells produce more collagen and heal faster, signs of younger skin. This reprogramming method could potentially be used to treat multiple age-related diseases, including Alzheimer’s disease and cataracts. If you could rewind the age… Continue reading Scientists Genetically Reprogram Human Skin Cells to be 30 Years Younger
Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy
Key Points: Deleting CD38 from mice restores heart function by correcting calcium homeostasis. Respiratory and muscle function are improved by deleting CD38. Inhibiting CD38 in human muscle cells corrects calcium homeostasis. Like buttress reinforcing the walls of a cathedral, there are proteins that reinforce the structure of our cells. When these proteins are compromised, cells… Continue reading Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy
NAD⁺ Restores Essential Clock for Muscle Repair
Key Points: Circadian clock malfunction hinders muscle repair by inhibiting the formation of new muscle cells after injury. Dysfunctional muscle formation is due to a shift from glucose to fat metabolism, reducing NAD+ levels. Boosting NAD+ restores SIRT1 gene modulation and muscle cell formation. Molecular clocks control many of our body’s biological processes, from our… Continue reading NAD⁺ Restores Essential Clock for Muscle Repair
Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Key Points In muscle, NAD+ is one of the most depleted metabolites associated with aging and the decline of physical ability. NAD+ levels are essentially the same in young adults and exercise-trained older adults. Boosting NAD+ is just one of the cellular processes underlying the benefits of exercise. Exercise isn’t just for looking good –… Continue reading Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Dasatinib Plus Quercetin Enhances Muscle Regeneration
Highlights: While certain activities like exercise can prolong muscle integrity as we age, our muscle’s regenerative potential inevitably crumbles. As we age, our muscles weaken due to the progressive elimination of satellite cells (muscle stem cells). These cells are imperative for skeletal muscle growth, development, and regeneration, but they shut down and stop proliferating, a… Continue reading Dasatinib Plus Quercetin Enhances Muscle Regeneration
Metformin Voids Benefits of Resistance Training
Highlights: Older adults with high muscle fats have the most improvements in physical performance in response to resistance exercise, independent of muscle size. Metformin blocks increased strength gained by resistance exercise in non-diabetic older adults with high muscle fats. Older adults who improved the most in response to resistance training had the highest levels of… Continue reading Metformin Voids Benefits of Resistance Training
Spacelike Microgravity Accelerates Aging and Causes Muscle Loss
Highlights: Resistance exercise alone isn’t enough to prevent age-related or microgravity-induced muscle loss. Aging and microgravity-related muscle loss stem from diminished muscle growth potential. Age-related and microgravity-induced muscle loss may share effective treatment options. In space, although astronauts appear weightless, they still depend on their muscles to live. Whether in space or down here on… Continue reading Spacelike Microgravity Accelerates Aging and Causes Muscle Loss
Restoring Age-Related Human Muscle Degeneration
Highlights Protein clumps called amyloid plaques accumulate during muscle aging and disease across species. Late-life NAD+ boosting reduces amyloid plaques during aging to improve healthspan and mitochondrial function. Aging is characterized by the imbalance of proteins — disrupted proteostasis — and dysfunctional mitochondria. These characteristics are often seen in age-related degenerative disorders with features like… Continue reading Restoring Age-Related Human Muscle Degeneration