Key Points As we get older, muscle deterioration and atrophy can drive low physical activity and ultimately, our loss of independence. A recent study in aged mice has shown that combining the diabetes medication metformin with the essential amino acid leucine can protect against diminished muscle function. How a metformin and leucine cocktail prevents muscle… Continue reading Metformin and Leucine Cocktail Prevents Muscle Atrophy and Cell Senescence: New Study
Category: Skin & Muscle
Coenzyme Q10 Defends Against Age-Related Physical Decline, Study Finds
Key Points: While the youth take advantage of their seemingly unbreakable bodies, adults are met with the inescapable reality of aging, with many succumbing to the inevitable decline of muscle function and fitness. Adults are burdened with these deficits, in part, due to impaired mitochondria – our cellular powerhouses – and brain dysfunction, which increases… Continue reading Coenzyme Q10 Defends Against Age-Related Physical Decline, Study Finds
New Hospital Study Shows Gene Therapy Reverses Muscle Aging
Key Points: One of the most increasingly pervasive diseases that continues to cripple the elderly population is sarcopenia, a condition characterized by the gradual loss of muscle mass, strength, and function. Although the underlying mechanisms behind this debilitating age-related disease remain unclear, new research from Nationwide Children’s Hospital (NCH) in Ohio suggests that the growth… Continue reading New Hospital Study Shows Gene Therapy Reverses Muscle Aging
High-Intensity but not Low-Intensity Exercise Acts as Senolytic: Taiwanese Study
Key Points: Most of our cells have short lifespans, dividing a few hundred times before entering replicative senescence — when a cell no longer divides. Not only do senescent cells not divide, but they can also cause organ damage if not removed. For this reason, the accumulation of senescent cells is thought to play a… Continue reading High-Intensity but not Low-Intensity Exercise Acts as Senolytic: Taiwanese Study
Study Shows Metformin Prevents Connective Tissue Aging
Key Points: Metformin has been used for decades to treat diabetes; however, many researchers have recently found that metformin has numerous anti-aging capabilities. A new study shows that metformin can be used to prevent another aging concern, the degradation of tendons – the connective tissue attaching muscles to bones. The study, from the University of… Continue reading Study Shows Metformin Prevents Connective Tissue Aging
New Study Shows Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness
Key Points: Aging inevitably compromises the regenerative potential of stem cells, leading to impaired tissue healing and muscle atrophy. Thus, identifying treatments that rejuvenate aged stem cells is vital to thwarting age-related conditions linked to poor stem cell function. Researchers have pinpointed a cell-cycle protein called Cdc42, the activity of which increases with aging and… Continue reading New Study Shows Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness
Young to Old Gut Bacteria Transfer Rejuvenates Muscle and Skin in Latest Study
Key Points: Some have likened our gut bacteria — the bacteria that live in our gut — to an organ. This “organ” is capable of modulating our immune system and metabolism, as well as other organs like the brain and muscle. However, our gut bacteria change with aging and may contribute to age-related diseases. This… Continue reading Young to Old Gut Bacteria Transfer Rejuvenates Muscle and Skin in Latest Study
Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study
Key Points As we grow older, our skin loses its vibrant appearance and begins to wrinkle. Age-associated wrinkles arise primarily from the loss of structural proteins called collagens. Recent research in rodents suggests senolytics – compounds that selectively eliminate senescent cells – reduce the abundance of the collagen-degrading inflammatory SASP and improve the function of… Continue reading Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study
New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging
Key Points: Stem cells have continuously been touted as a promising aging intervention, as they hold self-renewal and anti-inflammatory properties that contribute to organ rejuvenation and immune system regulation. However, stem cell therapy requires some refinement before it can be widely used. Recently, scientists have honed in on small fat packets secreted from stem cells… Continue reading New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging
Scientists find NAD⁺ Boosting Enzyme Protects Against Diabetes and Skeletal Muscle Decline
Key Points: The Nampt activator P7C3 lowers blood glucose while increasing insulin-secreting pancreatic β cells in diabetic mice. Treatment with P7C3 increases physical endurance, as well as muscle strength and size. P7C3 raises “good” cholesterol and lowers “bad” cholesterol. As the human population rises and the elderly population expands, unprecedented numbers of individuals with age-related… Continue reading Scientists find NAD⁺ Boosting Enzyme Protects Against Diabetes and Skeletal Muscle Decline