The transferring of electrons via metabolic pathways is essential to produce the energy required for human cells to function. To preserve this vital energy-producing process, electrons bind to nicotinamide adenine dinucleotide (NAD+), a crucial compound for cellular metabolism, and convert it to NADH. However, as humans age, the concentration of electrons and the ratio of… Continue reading Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
Month: September 2020
Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
Repetitive DNA strands called telomeres stop chromosome ends from fraying or sticking to each other, similar to plastic tips at the ends of shoelaces. These protective ends also ensure DNA gets copied correctly during cell replication. The length of telomeres is closely linked to aging, and when telomere length gets whittled down, cells age faster.… Continue reading Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
Gold Nanocrystal from Clene Nanomedicine Improves NAD⁺ Levels in Multiple Sclerosis and Parkinson’s Disease Patients
Multiple sclerosis is an inflammatory, demyelinating condition of the central nervous system that is the most prevalent inducer of neurological impairment in young adults, affecting almost one million people in the United States. In addition, approximately one-third of individuals with multiple sclerosis develop relapse multiple sclerosis, a progressive form of the illness for which there… Continue reading Gold Nanocrystal from Clene Nanomedicine Improves NAD⁺ Levels in Multiple Sclerosis and Parkinson’s Disease Patients
Mitochondrial NAD⁺ Transporter Identified
Baur and colleagues from the University of Pennsylvania School of Medicine reported in a study published in Nature that a cellular transporter, SLC25A51, allows the entry of an essential cellular coenzyme into the cell’s power-generating structure, the mitochondria. The essential coenzyme, nicotinamide adenine dinucleotide (NAD+), has crucial roles in mitochondrial cellular metabolism, where it converts… Continue reading Mitochondrial NAD⁺ Transporter Identified
Senolytics Prevent Inflammation and Bolster Aged Organ Survival Following Transplantation
In general, the solution to treat patients that exhibit end-stage organ failure is organ transplantation. While the supply and demand gap for organ transplantation is immense, there is potential in bridging this gap through the use of older organs. However, older organs tend not to be utilized in transplantation due to inducing elevated immune responses… Continue reading Senolytics Prevent Inflammation and Bolster Aged Organ Survival Following Transplantation