Highlights Human lung cells are transformed into senescent “zombie cells” by SARS-CoV-2. Drugs called senolytics can eliminate these once infected lung cells that have become senescent. Coronavirus may accelerate aspects of aging by induction of senescent lung cells. Coronavirus (SARS-CoV-2) just doesn’t seem to go away, and even when it does, it continues to cause… Continue reading Coronavirus Creates Zombie Cells that Fuel Post-Acute COVID-19 Syndrome
Month: January 2022
AI Zeroes In On Alzheimer’s Treatment
Highlights Artificial intelligence (AI) identified mitochondrial damage control molecules from a library of traditional Chinese medicinal plant compounds. Two of these molecules – Kaempferol and Rhapontigenin – reduce classic Alzheimer’s disease markers in worms and mice. Alzheimer’s disease mice fed Kaempferol and Rhapontigenin show improvements in spatial and visual memory. Alzheimer’s disease (AD) treatments are… Continue reading AI Zeroes In On Alzheimer’s Treatment
UPenn Researchers Engineer Immune Cells that Restore Heart Function
Key Points: When our hearts succumb to injury, our cells kick into high gear and activate cells that make up our connective tissue (fibroblasts), generating fibrous scar tissue in a process known as fibrosis. However, the continual accumulation of fibrous scar tissue rigifies the heart muscle, diminishing overall performance and contributing to the development of… Continue reading UPenn Researchers Engineer Immune Cells that Restore Heart Function
Japanese Researchers Show Fisetin Alleviates Depression
Highlights: Many lupus patients suffer from depression, the biological causes of which are not fully understood. Removing cells in an arrested state known as senescence from the brains of lupus mice reduces depression-like behavior. Senolytic compounds, drugs that target and remove senescent cells, could help treat depression in lupus patients. Senolytic compounds are an exciting… Continue reading Japanese Researchers Show Fisetin Alleviates Depression
David Sinclair: How to Change Your Diet to Live Longer
Highlights: In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant… Continue reading David Sinclair: How to Change Your Diet to Live Longer
Dasatinib Plus Quercetin Enhances Muscle Regeneration
Highlights: While certain activities like exercise can prolong muscle integrity as we age, our muscle’s regenerative potential inevitably crumbles. As we age, our muscles weaken due to the progressive elimination of satellite cells (muscle stem cells). These cells are imperative for skeletal muscle growth, development, and regeneration, but they shut down and stop proliferating, a… Continue reading Dasatinib Plus Quercetin Enhances Muscle Regeneration
Eli Lilly & Company’s Small Molecule Prevents Neurodegeneration
Highlights: The molecule DSRM-3716 stops SARM1 from breaking down NAD+. Blocking SARM1 changes the fate of axon degeneration. SARM1 inhibitors have the potential to treat many neurodegenerative diseases. When a nerve fiber is cut or crushed, the projection withers away starting from the tip and back to the cell body. This process occurs in many… Continue reading Eli Lilly & Company’s Small Molecule Prevents Neurodegeneration
Probiotic Improves Healthspan in Multiple Organisms
Highlights: A species of gut bacteria called B. adolescentis declines with aging in humans. Supplementation with B. adolescentis reverses osteoporosis, neurodegeneration, and other age-related conditions in mice. B. adolescentis could potentially be used as a probiotic to slow down the process of aging. Trillions of microscopic organisms live within our gut. Most of these microorganisms… Continue reading Probiotic Improves Healthspan in Multiple Organisms
Spermidine Improves Brain Inflammation and Anxiety
Highlights Long-term spermidine treatment does not extend lifespan in rats. Spermidine improves anxiety and inflammation in aged rats. Cell recycling processes (autophagy) are activated with spermidine treatment. In the early 2000s, scientists coined the term inflammaging to describe the close relationship between low-grade chronic inflammation and aging. Inflammaging has been linked to a broad spectrum… Continue reading Spermidine Improves Brain Inflammation and Anxiety