Key Takeaways: A class of metabolic activators improves critical cognitive function in Alzheimer’s patients, at least in those who are severely affected, according to a Phase II clinical study. Led by Istanbul Medipol University Hospital, the study claims that the combination of L-serine, N-acetyl cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate made the hippocampus,… Continue reading Study Shows Metabolic Activator Mix Reverses Cognitive Decline in Alzheimer’s Patients
Category: Brain & Neurons
Washington University Study: NMN Restores NAD⁺ in an Age-Modulating Brain Region
Key Points An important structure in the lower region of the brain called the hypothalamus regulates a myriad of physiological functions that are essential for our survival. These tasks include the control of body temperature, hunger, thirst, parenting behaviors, fatigue, and the sleep-wakefulness cycle (circadian rhythm). Due to its crucial roles in regulating physiological homeostasis,… Continue reading Washington University Study: NMN Restores NAD⁺ in an Age-Modulating Brain Region
NAD⁺- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study
Key Points Neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease, which facilitate the progressive deterioration of cognitive function, affect more than 50 million people globally. Research has linked mitochondrial dysfunction with neurodegenerative diseases but whether targeting functional aberrations of mitochondria can treat neurodegenerative diseases remains unclear. Published in Life Sciences, Mardinoglu and colleagues from King’s… Continue reading NAD⁺- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study
National Institute on Aging Finds NAD⁺ Booster Lowers Neurodegenerative Markers
Key Points: Our brain uses more energy than any other organ in the body. As such, brain cells are especially vulnerable to age-related depletion of nicotinamide adenine dinucleotide (NAD+), a central mediator of cellular energy production. It is, therefore, possible that NAD+ depletion contributes to neurodegeneration. Furthermore, replenishing NAD+ could potentially contribute to slowing or… Continue reading National Institute on Aging Finds NAD⁺ Booster Lowers Neurodegenerative Markers
New Study Shows Senolytics can Potentially Treat Alzheimer’s Disease
Key Points: Despite decades of research, no existing treatment stops the progression of AD. As early as the 90s, research suggested that senescent cells may contribute to AD, but this idea was dismissed because too many scientists believed neurons could not enter a senescent state. It is now known that senescent cells accumulate with age… Continue reading New Study Shows Senolytics can Potentially Treat Alzheimer’s Disease
Harvard Study Links Severe COVID-19 to Accelerated Brain Aging
Key Points Most people are aware of COVID-19’s debilitating respiratory symptoms, but many are unaware of the neurological symptoms. For example, many patients report a lack of focus, memory impairment, and depression. What’s more, on average, those who’ve had severe COVID-19 display diminished overall cognitive performance, suggesting severe infections may speed up age-related cognitive decline.… Continue reading Harvard Study Links Severe COVID-19 to Accelerated Brain Aging
Mayo Clinic Researchers Show Removing Senescent Immune Cells Prevents Cognitive Decline
Key Points: Increased inflammation is a critical symptom of aging, linked to cognitive decline and various age-related concerns. A new study shows that clearing senescent immune cells – aged cells which are permanently in a non-proliferating state and induce inflammation – from the brain may hold the key to preventing age-related cognitive issues. The study,… Continue reading Mayo Clinic Researchers Show Removing Senescent Immune Cells Prevents Cognitive Decline
USC Scientists Reveal that Fasting-Mimicking Diet Reduces Brain Pathology and Cognitive Decline in Alzheimer’s
Key Points: While many of us, including pharmaceutical companies, hope that AD can be cured with therapeutic drugs, a new study from the University of Southern California (USC) suggest that such drugs may be unnecessary. Published in Cell Reports, Rangan and colleagues show that FMD reduces brain inflammation and cognitive decline in a mouse model… Continue reading USC Scientists Reveal that Fasting-Mimicking Diet Reduces Brain Pathology and Cognitive Decline in Alzheimer’s
Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Key Points: Aging is multifaceted and complex, involving a myriad of interacting biological pathways that gradually collapse and lead to organ and tissue dysfunction. Many of the current anti-aging therapeutics target only one specific biological pathway, narrowing their impact on slowing, preventing, or reversing aging. This is why scientists have turned to drug combinations that… Continue reading Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage
Dublin Scientists Develop Gene Therapy for Eye Degeneration
Key Points: A gene called NDI1 is delivered to mouse and human cell models for age-related macular degeneration (AMD) as therapy. NDI1 therapy reduces molecules called reactive oxygen species (ROS) while raising nicotinamide adenine dinucleotide (NAD+) levels. Treatment with NDI1 recovers the function of mitochondria — key modulators of cell health and aging. To visualize… Continue reading Dublin Scientists Develop Gene Therapy for Eye Degeneration