Category: Brain & Neurons

Key Points:  A gene called NDI1 is delivered to mouse and human cell models for age-related macular degeneration (AMD) as therapy.  NDI1 therapy reduces molecules called reactive oxygen species (ROS) while raising nicotinamide adenine dinucleotide (NAD+) levels.  Treatment with NDI1 recovers the function of mitochondria — key modulators of cell health and aging. To visualize… Continue reading Dublin Scientists Develop Gene Therapy for Eye Degeneration 

Key Points:  Dozens of potentially doctored images were found in scientific publications that laid the groundwork for current theories of Alzheimer’s disease (AD) progression. Therapies based on these theories have failed in clinical trials, leading to questions regarding these initial claims. For a long-time now, over a decade, it’s been thought that researchers were on… Continue reading Falsified Data Could Set Alzheimer’s Research Back 16 Years

Key Points:  Our cells utilize hundreds of enzymes to operate on a daily basis, yet few are well-renowned for their lifespan-extending and anti-aging effects as sirtuins. Considering that disorders like Parkinson’s and Alzheimer’s disease are a consequence of aging, enhancing the activity of sirtuin enzymes may provide a key to treating these incurable diseases. In… Continue reading Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models

Key Points: 8.5% of unvaccinated older adults developed Alzheimer’s after four years, while 5.1% developed the disease if vaccinated.  Regular annual flu vaccinations are predicted to reduce Alzheimer’s disease incidence further. In the past few years, the topic of flu vaccinations has been fairly polarizing, with many of the general public indicating that the flu… Continue reading UTHealth Researchers Show Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk

Key Points: Treatment with plasmalogens improves the learning and memory of aged mice. Aged mice treated with plasmalogens have a healthier appearance with glossier fur.  Plasmolgens promote the generation of new neurons while reducing inflammation.  The connections between the neurons in our brain begin to dwindle as we age, leading to cognitive deficits such as… Continue reading Study Finds Fat Molecules that Improve Age-Related Cognitive Deficits

Key Points:  The gum disease-assocaited bacteria F. nucleatum lowers cognitive function in mice.  The brain tissue of mice with gum disease exhibit significantly higher levels of amyloid beta (Aβ) and phosphorylated-tau (p-Tau), both hallmarks of Alzheimer’s disease progression.  Mice with gum disease also have elevated brain inflammation.  The CDC confirms that nearly 50% of adults… Continue reading Gum Disease Pathogen Fusobacterium nucleatum May Increase Alzheimer’s Risk

Key points:  Treating aged mice with the anti-aging protein klotho improves their spatial and short-term memory.  Klotho and cognitive stimulation activate overlapping metabolites in young mice, suggesting that klotho mimics cognitive stimulation.  Klotho was named after one of the Fates, the Greek goddess Clotho, who spins the thread of life. It was named so by… Continue reading Study Suggest Anti-Aging Protein Mimics Mental Stimulation in Mice

Key Points:  Agomelatine improves the memory and learning of Alzheimer’s mice by enhancing autophagy — the cellular waste clearance system that deteriorates with age. Antidepressant drugs could potentially treat the cognitive deficits associated with Alzheimer’s disease. None of us are safe from Alzheimer’s disease (AD), as 90% of cases are sporadic. For those already diagnosed,… Continue reading Study Shows Agomelatine Prevents Cognitive Deficits in Alzheimer’s