Key Points: In response to cold, our fat stem cells have the remarkable capability of developing into beige fat cells. Once generated, beige fat cells burn the sugar and fats circulating in our bloodstream to produce heat instead of energy. However, our stem cells decline with age, and the beiging process begins to fail as… Continue reading Cornell Scientists Repurpose Cancer Drugs to Rejuvenate Weight-Loss Promoting Beige Fat Cells
Category: Metabolism
Taking Vitamin B9 Enhances Memory and Counters Brain Deterioration, Study Finds
Key Points: Proper nourishment is critical to maintaining the aging brain’s resilience and vitality. Failure to do so makes this nimble organ increasingly vulnerable to damage, leading to cognitive dysfunction and memory decline. Of the many brain-boosting vitamins, minerals, and antioxidants, researchers have pinpointed folic acid (vitamin B9) as central to nervous system health and neuronal… Continue reading Taking Vitamin B9 Enhances Memory and Counters Brain Deterioration, Study Finds
A New Pharmaceutical Targeting Both NAD⁺ and mTOR Pathways Shows Efficacy Against NASH and ALS
Key Points The geroscience hypothesis proposes that a therapeutic treating an underlying aging process should prevent multiple age-related diseases. Two examples of pathways that researchers have targeted to treat multiple aging-associated conditions are NAD+ metabolism and the mTOR pathway. Yet how these two pathways relate to one another and whether drugs can target both simultaneously… Continue reading A New Pharmaceutical Targeting Both NAD⁺ and mTOR Pathways Shows Efficacy Against NASH and ALS
Study Reveals How Stress Accelerates Aging: Columbia University
Key Points: Our psychological stress is associated with elevated levels of the stress hormone cortisol and an up to 67% increase in whole-body energy expenditure. In response to stress, our cells increase survival processes to promote resilience, termed allostasis. However, chronic activation of allostasis — allostatic overload — could contribute to cellular aging. Now, a new study… Continue reading Study Reveals How Stress Accelerates Aging: Columbia University
Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults
Key Points Research has shown that cellular levels of the essential molecule for cell energy generation, mitochondrial production, and DNA repair – nicotinamide adenine dinucleotide (NAD+) – drop as we age. Scientists have postulated that this age-related declining cellular NAD+ contributes to age-associated diseases. Rodent studies have shown that NAD+ augmentation improves healthspan by enhancing… Continue reading Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults
Study Shows Metabolic Activator Mix Reverses Cognitive Decline in Alzheimer’s Patients
Key Takeaways: A class of metabolic activators improves critical cognitive function in Alzheimer’s patients, at least in those who are severely affected, according to a Phase II clinical study. Led by Istanbul Medipol University Hospital, the study claims that the combination of L-serine, N-acetyl cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate made the hippocampus,… Continue reading Study Shows Metabolic Activator Mix Reverses Cognitive Decline in Alzheimer’s Patients
University of Arizona Study Shows Moderate Calorie-Restricted Diet Improves Metabolism and Physical Function
Key Points Residents of Okinawa consume, on average, 11% fewer calories than others around the world, have lower body fat, and exhibit reduced mortality from age-related diseases. Although these tantalizing data show a correlation between reducing calorie intake and healthier aging, they don’t establish a causal link. Furthermore, most animal studies showing that caloric restriction… Continue reading University of Arizona Study Shows Moderate Calorie-Restricted Diet Improves Metabolism and Physical Function
Russia Study Shows Immucillin H Enhances NR’s NAD⁺ Boosting Effect
Key Points: Our cells demand adequate NAD+ levels to fuel enzymes that modulate cell survival. As we age, our cells accumulate damage, namely to DNA, increasing the need for survival enzymes and raising the demand for NAD+. However, when these demands are unmet, cells die, organs degenerate, and disease ensues. This is why replenishing NAD+… Continue reading Russia Study Shows Immucillin H Enhances NR’s NAD⁺ Boosting Effect
Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration, Study Shows
Key Points: Alzheimer’s mice fed a ketogenic diet have improved spatial and short-term memory. The ketogenic diet largely restores the loss of neurons, neuronal connections, and neuron degeneration in Alzheimer’s mice. The effects of the ketogenic diet are mediated by reduced brain inflammation. When challenged with inflammation over a lifetime, our organs operate with declining… Continue reading Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration, Study Shows
Korean Study Shows Vitamin B₃ Alleviates Diabetes-Induced Eye Degeneration
Key Points: Vitamin B3 (nicotinamide) treatment reduces cell death and injury in the retinas of rats modeling diabetes. Treatment with nicotinamide enhances DNA repair in the retinas of diabetic rats. Among the myriad of risks associated with diabetes, one that severely impacts life quality is blindness, which stems from the deterioration of the retina –… Continue reading Korean Study Shows Vitamin B₃ Alleviates Diabetes-Induced Eye Degeneration