Key Points: The Nampt activator P7C3 lowers blood glucose while increasing insulin-secreting pancreatic β cells in diabetic mice. Treatment with P7C3 increases physical endurance, as well as muscle strength and size. P7C3 raises “good” cholesterol and lowers “bad” cholesterol. As the human population rises and the elderly population expands, unprecedented numbers of individuals with age-related… Continue reading Scientists find NAD⁺ Boosting Enzyme Protects Against Diabetes and Skeletal Muscle Decline
Category: Metabolism
Study Suggests Tomato Antioxidant Prevents Signs of Diabetes and Reverses Blood Vessel Aging
Key Points: Supplementing aged rats with lycopene increases the growth of blood vessels in muscle. Blood vessel growth is induced by reduced insulin resistance — a primary cause of type 2 diabetes — allowing for improved glucose (energy) utilization. Blood vessel restoration is regulated by SIRT1, a guardian protein that plays a vital role in… Continue reading Study Suggests Tomato Antioxidant Prevents Signs of Diabetes and Reverses Blood Vessel Aging
UCSD Study Shows Eating within 8-Hour Window Elevates Beneficial Gut Bacteria Molecule
Key Points: Obese mice have a dysregulated gut microbiome (bacteria and other microbes in the intestines) that is restored by eating within an 8-hour window. This time-restricted feeding improves sugar and fat metabolism, preventing weight gain. Time-restricted feeding also leads to the gut microbiome producing more GLP-1, a molecule that improves sugar metabolism. Our bodies… Continue reading UCSD Study Shows Eating within 8-Hour Window Elevates Beneficial Gut Bacteria Molecule
Study Shows NAD⁺ Precursor Prevents Diet-Induced Weight Gain in Female Mice
Key Points: NR supplementation decreases weight gain, fat mass accumulation, and elevation in cholesterol associated with obesity and aging. Supplementation with NR reduces inflammation, a hallmark of aging, in fat tissue. NR treatment also elevates metabolism and enhances physical activity levels. Nicotinamide riboside (NR) is a molecule capable of raising the declining levels of nicotinamide… Continue reading Study Shows NAD⁺ Precursor Prevents Diet-Induced Weight Gain in Female Mice
Study Shows Sesamol Prevents Weight Gain and Improves Metabolism in Middle-Aged Mice
Key Points: Sesamol treatment prevents high-fat diet-induced obesity in middle-aged mice. Treatment with sesamol prevents obesity-induced metabolic syndrome. Sesamol activates longevity-associated proteins AMPK and SIRT1. The sesame seeds on your Big Mac won’t help you lose weight, but according to a new study published in Food & Nutrition Research, sesamol — a compound present in… Continue reading Study Shows Sesamol Prevents Weight Gain and Improves Metabolism in Middle-Aged Mice
Sulforaphane — a Compound in Broccoli — Fights Off Fat
Key Points: A compound derived from broccoli called sulforaphane induces weight loss and improves blood sugar levels in obese mice. Sulforaphane prevents weight gain in lean mice fed a high-fat diet. Two billion people in the world are either obese or overweight. That’s over a quarter of the world’s population. As the rate of obesity… Continue reading Sulforaphane — a Compound in Broccoli — Fights Off Fat
Using Metabolites in Saliva, Japanese Researchers Measure Aging
Key Points: · Teruya and colleagues identify 21 age-linked compounds in human saliva. · Only one metabolite increased in older subjects: ATP, the cell’s energy currency.· Saliva from older subjects had lower levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. Throughout the COVID-19 pandemic, many people have monitored their ability to taste,… Continue reading Using Metabolites in Saliva, Japanese Researchers Measure Aging
New Anti-Aging Supplement Mitopure Promotes Microbiome Health
Highlights: Even if you follow the food pyramid’s guidelines, eating optimal portions of each food group, you still may not get all the necessary nutrients. That happens, in part, because if we don’t have the right mix of microbes in our guts — the microbiome — then we can’t convert food into the nutrients needed… Continue reading New Anti-Aging Supplement Mitopure Promotes Microbiome Health
The Science Behind Adele’s Weight Loss
Most of us know that health and longevity go hand in hand with our dietary choices, which has led to many people paying close attention to what they eat. Although reducing calorie intake and fasting are proven weight loss and longevity-promoting methods, they’re not easy or exciting things to do every day. But wouldn’t it… Continue reading The Science Behind Adele’s Weight Loss
Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
The transferring of electrons via metabolic pathways is essential to produce the energy required for human cells to function. To preserve this vital energy-producing process, electrons bind to nicotinamide adenine dinucleotide (NAD+), a crucial compound for cellular metabolism, and convert it to NADH. However, as humans age, the concentration of electrons and the ratio of… Continue reading Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity