Key Points: NR supplementation decreases weight gain, fat mass accumulation, and elevation in cholesterol associated with obesity and aging. Supplementation with NR reduces inflammation, a hallmark of aging, in fat tissue. NR treatment also elevates metabolism and enhances physical activity levels. Nicotinamide riboside (NR) is a molecule capable of raising the declining levels of nicotinamide… Continue reading Study Shows NAD⁺ Precursor Prevents Diet-Induced Weight Gain in Female Mice
Category: Metabolism
Study Shows Sesamol Prevents Weight Gain and Improves Metabolism in Middle-Aged Mice
Key Points: Sesamol treatment prevents high-fat diet-induced obesity in middle-aged mice. Treatment with sesamol prevents obesity-induced metabolic syndrome. Sesamol activates longevity-associated proteins AMPK and SIRT1. The sesame seeds on your Big Mac won’t help you lose weight, but according to a new study published in Food & Nutrition Research, sesamol — a compound present in… Continue reading Study Shows Sesamol Prevents Weight Gain and Improves Metabolism in Middle-Aged Mice
Sulforaphane — a Compound in Broccoli — Fights Off Fat
Key Points: A compound derived from broccoli called sulforaphane induces weight loss and improves blood sugar levels in obese mice. Sulforaphane prevents weight gain in lean mice fed a high-fat diet. Two billion people in the world are either obese or overweight. That’s over a quarter of the world’s population. As the rate of obesity… Continue reading Sulforaphane — a Compound in Broccoli — Fights Off Fat
Using Metabolites in Saliva, Japanese Researchers Measure Aging
Key Points: · Teruya and colleagues identify 21 age-linked compounds in human saliva. · Only one metabolite increased in older subjects: ATP, the cell’s energy currency.· Saliva from older subjects had lower levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. Throughout the COVID-19 pandemic, many people have monitored their ability to taste,… Continue reading Using Metabolites in Saliva, Japanese Researchers Measure Aging
New Anti-Aging Supplement Mitopure Promotes Microbiome Health
Highlights: Even if you follow the food pyramid’s guidelines, eating optimal portions of each food group, you still may not get all the necessary nutrients. That happens, in part, because if we don’t have the right mix of microbes in our guts — the microbiome — then we can’t convert food into the nutrients needed… Continue reading New Anti-Aging Supplement Mitopure Promotes Microbiome Health
The Science Behind Adele’s Weight Loss
Most of us know that health and longevity go hand in hand with our dietary choices, which has led to many people paying close attention to what they eat. Although reducing calorie intake and fasting are proven weight loss and longevity-promoting methods, they’re not easy or exciting things to do every day. But wouldn’t it… Continue reading The Science Behind Adele’s Weight Loss
Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
The transferring of electrons via metabolic pathways is essential to produce the energy required for human cells to function. To preserve this vital energy-producing process, electrons bind to nicotinamide adenine dinucleotide (NAD+), a crucial compound for cellular metabolism, and convert it to NADH. However, as humans age, the concentration of electrons and the ratio of… Continue reading Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
Mitochondrial NAD⁺ Transporter Identified
Baur and colleagues from the University of Pennsylvania School of Medicine reported in a study published in Nature that a cellular transporter, SLC25A51, allows the entry of an essential cellular coenzyme into the cell’s power-generating structure, the mitochondria. The essential coenzyme, nicotinamide adenine dinucleotide (NAD+), has crucial roles in mitochondrial cellular metabolism, where it converts… Continue reading Mitochondrial NAD⁺ Transporter Identified
Binge Drinking-Induced Liver Damage Results From Reduced Cell NAD⁺ Levels
Consuming alcohol can provide a welcome reprieve from the hassles of every-day life but can lead to binge drinking and excessive alcohol consumption. Over time, too much alcohol use results in developing chronic diseases and other serious problems. UCLA scientist and pathologist Dr. Samuel French published a review on the effects of chronic alcohol binging… Continue reading Binge Drinking-Induced Liver Damage Results From Reduced Cell NAD⁺ Levels