Key Points: Senescent cells — dysfunctional cells that emit inflammatory molecules — accumulate as we grow older, and their elimination may serve as a way to revitalize tissues and increase the number of disease-free years we live. As such, it is paramount to identify compounds that mitigate the age-related elevations in senescent cells. This has… Continue reading New Study Reveals Green Tea Molecule Extends Lifespan and Alleviates Fat Tissue Senescence
Category: Aging & Longevity
Living Longevity Experiment Bryan Johnson: Is it Possible to Exercise Too Much?
Key Points: Bryan Johnson is an entrepreneur turned millionaire who has said, “I want to go to the absolute limits of what’s possible in the form of slowing my speed of aging.” While this is no small task, as part of his age-slowing regimen, Johnson exercises for an hour a day. He says that during… Continue reading Living Longevity Experiment Bryan Johnson: Is it Possible to Exercise Too Much?
Study Shows Avoiding Consumption of Protein Building Block Isoleucine Increases Lifespan
Key Points: Since finding that caloric restriction (CR) — eating fewer calories — extends the lifespan of animals, scientists have searched for interventions that mimic CR. This is because, in countries like the USA, widespread availability and affordability of calorie-dense foods often challenge people to regulate their consumption of tempting calories throughout the day. Now, researchers from… Continue reading Study Shows Avoiding Consumption of Protein Building Block Isoleucine Increases Lifespan
Harvard Scientist David Sinclair’s Techniques for Reducing His Biological Age by a Decade
Key Points: Harvard’s David Sinclair maintains a biological age a whole decade younger than his chronological age. Biological age can be measured with blood markers like sugar (glucose) levels/patterns of DNA tagging (methylation). From these, a biological age that is lower than one’s chronological age is indicative of decelerated aging. The notable reduction in Sinclair’s… Continue reading Harvard Scientist David Sinclair’s Techniques for Reducing His Biological Age by a Decade
Researchers Use Gold Nanoparticles to Treat Neurodegenerative Disease
Key Points: Alzheimer’s disease is a progressive neurological disorder characterized by memory loss, cognitive decline, and behavioral changes due to the degeneration and death of brain cells. These changes in the brain are thought to be caused by the buildup of abnormal protein in the brain, causing damage and eventually killing brain cells. In this… Continue reading Researchers Use Gold Nanoparticles to Treat Neurodegenerative Disease
Study Reveals Surprising Benefits of Grapeseed Flour: Increased Lifespan and Multi-Organ NAD+ Rejuvenation
Key Points: It was once thought that molecules called reactive oxygen species (ROS) — which are oxidants — cause the adverse health effects associated with aging. Therefore, consuming anti-oxidants, abundant in plant-based foods, was hypothesized to counteract age-related diseases. While this isn’t the whole story, this theory may not be far from the truth. In… Continue reading Study Reveals Surprising Benefits of Grapeseed Flour: Increased Lifespan and Multi-Organ NAD+ Rejuvenation
Stanford’s Dr. Andrew Huberman Takes Two NAD+ Precursors Daily: NMN and NR
Key Points: Andrew Huberman is a professor of neurobiology and ophthalmology at Stanford School of Medicine. He also hosts the Huberman Lab podcast where he “discusses science and science-based tools for everyday life.” In an Ask Me Anything (AMA) episode of the podcast, Huberman was asked, “There seems to be a lot of conjecture about… Continue reading Stanford’s Dr. Andrew Huberman Takes Two NAD+ Precursors Daily: NMN and NR
Cedars-Sinai Scientists Identify Stem Cell-Secreted Particles that Boost Lifespan and Endurance
Key Points: Today it seems possible to treat multiple age-related diseases, including cardiovascular disease and diabetes with a single treatment. Now researchers from Cedars-Sinai Medical Center in Los Angeles may have discovered such a treatment. As reported in Scientific Reports, Shamagian and colleagues show that stem cell EVs prolong the lifespan of old rats. They… Continue reading Cedars-Sinai Scientists Identify Stem Cell-Secreted Particles that Boost Lifespan and Endurance
New Pill Increases Male Mouse Lifespan, Study Shows
Key Points: Researchers from the University of Alabama at Birmingham and Indiana University at Bloomington discovered that male mice given a pill made of a pharmaceutical-grade compound from a young age had a significantly longer lifespan than male mice that did not receive the pill. The pill contained an agonist for ghrelin, a molecule produced… Continue reading New Pill Increases Male Mouse Lifespan, Study Shows
Citrus Compound Significantly Increases Lifespan and Healthspan in Aging Models
Key Points: Researchers from several Shanghai universities collaborated in a study showing that a naturally-occurring compound in citrus fruits—such as lemons, grapefruits, oranges, and tangerines—extends lifespan and healthspan in animals. In roundworms, nomilin increased lifespan by 24%, which the researchers report occurs through a mechanism that enhances detoxification pathway activity. In mouse models of premature… Continue reading Citrus Compound Significantly Increases Lifespan and Healthspan in Aging Models