Key points: Sirtuins – enzymes that use the aging-related vital molecule NAD+ as fuel – play key roles in longevity. These longevity-linked proteins maintain cellular health and are known to participate in DNA repair and stability. However, the extent to which sirtuins contribute to prolonging lifespan across species is still not clear. On the heels… Continue reading Sirtuin 6 Increases Resistance to Oxidative Stress, Inhibits Protein Generation, and Prolongs Lifespan in Flies
Category: Aging & Longevity
What Drives Aging?
Key Points: NAD+ declines with age largely due to the activation of CD38, an enzyme activated by the inflammation produced by senescent cells – cells that no longer grow or replicate. In a feed-forward cycle, the decline of NAD+ by CD38 induces the spread of more senescent cells and inflammation. Halting this cycle could prevent… Continue reading What Drives Aging?
Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Key Points In muscle, NAD+ is one of the most depleted metabolites associated with aging and the decline of physical ability. NAD+ levels are essentially the same in young adults and exercise-trained older adults. Boosting NAD+ is just one of the cellular processes underlying the benefits of exercise. Exercise isn’t just for looking good –… Continue reading Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Clinical Study Suggests When to Start Taking NAD⁺ Boosters to Improve Exercise
Key Points: 500 mg of NR supplementation for ten days reduces oxidative stress and increases exercise performance in old but not young men. Reduced oxidative stress and enhanced physical performance in older men may be due to increased NADH and NADPH. NAD+ is an important molecule that keeps our cells, organs, and bodies alive. Because… Continue reading Clinical Study Suggests When to Start Taking NAD⁺ Boosters to Improve Exercise
Caloric Restriction Decreases Inflammation in Humans
Highlights: Restricting caloric intake by 14% prevents the shrinkage of the thymus, an immune system organ that deteriorates with aging. The immune system of fat tissue is less inflammatory in calorically restricted participants. A gene called PLA2G7 mediates the benefits of caloric restriction and is a potential mimetic of caloric restriction. Whether eating fewer calories… Continue reading Caloric Restriction Decreases Inflammation in Humans
“Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
Highlights A DNA variant in the gene BPIFB4 is shared amongst long-living individuals. This longevity linked DNA variant eliminates senescent cells and rejuvenates NAD+ levels in mice. Long-living individuals, especially those with the longevity variant in BPIFB4, have higher NAD+ levels than elderly adults. What makes us live longer? The food we eat, the amount… Continue reading “Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
David Sinclair: How to Change Your Diet to Live Longer
Highlights: In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant… Continue reading David Sinclair: How to Change Your Diet to Live Longer
Probiotic Improves Healthspan in Multiple Organisms
Highlights: A species of gut bacteria called B. adolescentis declines with aging in humans. Supplementation with B. adolescentis reverses osteoporosis, neurodegeneration, and other age-related conditions in mice. B. adolescentis could potentially be used as a probiotic to slow down the process of aging. Trillions of microscopic organisms live within our gut. Most of these microorganisms… Continue reading Probiotic Improves Healthspan in Multiple Organisms
Using Metabolites in Saliva, Japanese Researchers Measure Aging
Key Points: · Teruya and colleagues identify 21 age-linked compounds in human saliva. · Only one metabolite increased in older subjects: ATP, the cell’s energy currency.· Saliva from older subjects had lower levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. Throughout the COVID-19 pandemic, many people have monitored their ability to taste,… Continue reading Using Metabolites in Saliva, Japanese Researchers Measure Aging
Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy
Highlights A genome-wide CRISPR-Cas9-based screen was utilized by Wang et al. to locate genes that could affect cellular senescence. KAT7 was shown to be a promoter of senescence in stem cells of adult humans. Extension of mice life span and rejuvenation of premature aged progeroid humans cells resulted from inactivation of KAT7. While we… Continue reading Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy