Key Points: Circadian clock malfunction hinders muscle repair by inhibiting the formation of new muscle cells after injury. Dysfunctional muscle formation is due to a shift from glucose to fat metabolism, reducing NAD+ levels. Boosting NAD+ restores SIRT1 gene modulation and muscle cell formation. Molecular clocks control many of our body’s biological processes, from our… Continue reading NAD⁺ Restores Essential Clock for Muscle Repair
Category: Aging & Longevity
Mayo Study Shows Senolytics Increase Anti-Aging Protein
Key Points: Senescent cells — an aging-linked state of permanent cell cycle arrest — from various human tissues reduce levels of the anti-aging protein α-klotho. Senolytics — compounds targeting and removing senescent cells — boost α-klotho levels in aged, obese, and senescent cell-transplanted mice. Urinary α-Klotho may be a valuable test for following treatments in… Continue reading Mayo Study Shows Senolytics Increase Anti-Aging Protein
Study Shows Organs Can Age at Different Speeds
Key Points: Our organs are like parts of a biological machine, working together to keep us alive. If one part of the machine becomes old and damaged, the whole machine can break down. To help prevent this inevitable system failure, we can assess the condition of each part. We could even predict how long the… Continue reading Study Shows Organs Can Age at Different Speeds
Cellular Rejuvenation Therapy Safely Reverses Mouse Aging
Key Points: The activation of reprogramming factors – proteins that can turn mature cells back into stem cells – in mice safely rejuvenates skin and kidneys. The rejuvenating effects reduce the activation of genes involved in several age-related pathways, including inflammation, stress, and senescence. The clocks of aging, as measured by changes to patterns in… Continue reading Cellular Rejuvenation Therapy Safely Reverses Mouse Aging
Mayo Clinic Finds That Inhibiting NAD+ Breakdown Increases Lifespan and Prevents Age-Related Physical Decline in Mice
Key Points: The CD38 inhibitor 78c increases the longevity of male but not female mice. The age-related decline in exercise performance is prevented by 78c in the diet. Feeding mice 78c improves several age-related conditions and increases NAD+ levels in multiple organs. NAD+ (nicotinamide adenine dinucleotide) declines with aging in parallel with the health of… Continue reading Mayo Clinic Finds That Inhibiting NAD+ Breakdown Increases Lifespan and Prevents Age-Related Physical Decline in Mice
Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Key Points: When people experience serious adversity, particularly a natural disaster, it can appear as if they’ve aged rapidly. New research shows that a survivor’s superficial and emotional wear and tear are might actually reflect what’s going on inside as natural disasters accelerate biological aging at the DNA level. In a new study published in… Continue reading Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Key Points: Obesity due to a high-fat diet causes subfertility – fewer mature oocytes (eggs) and smaller litters in mice. Supplementing with nicotinamide riboside (NR), an NAD+ precursor, alleviates the obesity-induced subfertility. These findings suggest that NAD+ boosting through precursor supplementation could be a potential therapy for diet-induced subfertility. Infertility is on the rise, currently… Continue reading Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Sirtuin 6 Increases Resistance to Oxidative Stress, Inhibits Protein Generation, and Prolongs Lifespan in Flies
Key points: Sirtuins – enzymes that use the aging-related vital molecule NAD+ as fuel – play key roles in longevity. These longevity-linked proteins maintain cellular health and are known to participate in DNA repair and stability. However, the extent to which sirtuins contribute to prolonging lifespan across species is still not clear. On the heels… Continue reading Sirtuin 6 Increases Resistance to Oxidative Stress, Inhibits Protein Generation, and Prolongs Lifespan in Flies
What Drives Aging?
Key Points: NAD+ declines with age largely due to the activation of CD38, an enzyme activated by the inflammation produced by senescent cells – cells that no longer grow or replicate. In a feed-forward cycle, the decline of NAD+ by CD38 induces the spread of more senescent cells and inflammation. Halting this cycle could prevent… Continue reading What Drives Aging?
Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Key Points In muscle, NAD+ is one of the most depleted metabolites associated with aging and the decline of physical ability. NAD+ levels are essentially the same in young adults and exercise-trained older adults. Boosting NAD+ is just one of the cellular processes underlying the benefits of exercise. Exercise isn’t just for looking good –… Continue reading Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺