Key Points: The CD38 inhibitor 78c increases the longevity of male but not female mice. The age-related decline in exercise performance is prevented by 78c in the diet. Feeding mice 78c improves several age-related conditions and increases NAD+ levels in multiple organs. NAD+ (nicotinamide adenine dinucleotide) declines with aging in parallel with the health of… Continue reading Mayo Clinic Finds That Inhibiting NAD+ Breakdown Increases Lifespan and Prevents Age-Related Physical Decline in Mice
Category: Aging & Longevity
Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Key Points: When people experience serious adversity, particularly a natural disaster, it can appear as if they’ve aged rapidly. New research shows that a survivor’s superficial and emotional wear and tear are might actually reflect what’s going on inside as natural disasters accelerate biological aging at the DNA level. In a new study published in… Continue reading Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Key Points: Obesity due to a high-fat diet causes subfertility – fewer mature oocytes (eggs) and smaller litters in mice. Supplementing with nicotinamide riboside (NR), an NAD+ precursor, alleviates the obesity-induced subfertility. These findings suggest that NAD+ boosting through precursor supplementation could be a potential therapy for diet-induced subfertility. Infertility is on the rise, currently… Continue reading Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Sirtuin 6 Increases Resistance to Oxidative Stress, Inhibits Protein Generation, and Prolongs Lifespan in Flies
Key points: Sirtuins – enzymes that use the aging-related vital molecule NAD+ as fuel – play key roles in longevity. These longevity-linked proteins maintain cellular health and are known to participate in DNA repair and stability. However, the extent to which sirtuins contribute to prolonging lifespan across species is still not clear. On the heels… Continue reading Sirtuin 6 Increases Resistance to Oxidative Stress, Inhibits Protein Generation, and Prolongs Lifespan in Flies
What Drives Aging?
Key Points: NAD+ declines with age largely due to the activation of CD38, an enzyme activated by the inflammation produced by senescent cells – cells that no longer grow or replicate. In a feed-forward cycle, the decline of NAD+ by CD38 induces the spread of more senescent cells and inflammation. Halting this cycle could prevent… Continue reading What Drives Aging?
Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Key Points In muscle, NAD+ is one of the most depleted metabolites associated with aging and the decline of physical ability. NAD+ levels are essentially the same in young adults and exercise-trained older adults. Boosting NAD+ is just one of the cellular processes underlying the benefits of exercise. Exercise isn’t just for looking good –… Continue reading Nature Aging Study Shows that Exercise May Prevent Age-Related Muscle Decline by Boosting NAD⁺
Clinical Study Suggests When to Start Taking NAD⁺ Boosters to Improve Exercise
Key Points: 500 mg of NR supplementation for ten days reduces oxidative stress and increases exercise performance in old but not young men. Reduced oxidative stress and enhanced physical performance in older men may be due to increased NADH and NADPH. NAD+ is an important molecule that keeps our cells, organs, and bodies alive. Because… Continue reading Clinical Study Suggests When to Start Taking NAD⁺ Boosters to Improve Exercise
Caloric Restriction Decreases Inflammation in Humans
Highlights: Restricting caloric intake by 14% prevents the shrinkage of the thymus, an immune system organ that deteriorates with aging. The immune system of fat tissue is less inflammatory in calorically restricted participants. A gene called PLA2G7 mediates the benefits of caloric restriction and is a potential mimetic of caloric restriction. Whether eating fewer calories… Continue reading Caloric Restriction Decreases Inflammation in Humans
“Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
Highlights A DNA variant in the gene BPIFB4 is shared amongst long-living individuals. This longevity linked DNA variant eliminates senescent cells and rejuvenates NAD+ levels in mice. Long-living individuals, especially those with the longevity variant in BPIFB4, have higher NAD+ levels than elderly adults. What makes us live longer? The food we eat, the amount… Continue reading “Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
David Sinclair: How to Change Your Diet to Live Longer
Highlights: In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant… Continue reading David Sinclair: How to Change Your Diet to Live Longer