Highlights A genome-wide CRISPR-Cas9-based screen was utilized by Wang et al. to locate genes that could affect cellular senescence. KAT7 was shown to be a promoter of senescence in stem cells of adult humans. Extension of mice life span and rejuvenation of premature aged progeroid humans cells resulted from inactivation of KAT7. While we… Continue reading Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy
Category: Aging & Longevity
How Does Space Travel Affect Natural Aging?
Growing older can take a serious toll on the body. Bones become brittle, muscle shrinks, the immune system loses strength, and age-related ailments like arthritis can set in. More serious complications like declining cognitive function and heart disease can also take hold as the later years of life progress. These symptoms can also come from… Continue reading How Does Space Travel Affect Natural Aging?
Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner
Highlights Male mouse survival is significantly enhanced through late-life rapamycin administration regimens. Female mouse survival was also improved through continuous rapamycin administration. As males and females have different life expectancies, there are likely to be aging variations between them. However, it is still unclear if there is a connection between these variations in aging and… Continue reading Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner
Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
The transferring of electrons via metabolic pathways is essential to produce the energy required for human cells to function. To preserve this vital energy-producing process, electrons bind to nicotinamide adenine dinucleotide (NAD+), a crucial compound for cellular metabolism, and convert it to NADH. However, as humans age, the concentration of electrons and the ratio of… Continue reading Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
NAD⁺ Regulating Enzyme Keeps Mouse Cells Replicating Under Stress
Aging revolves around cellular senescence, a state of cell arrest. Extreme stress levels or cell proliferation can lead to the accumulation of senescent cells, which limits the capacity of tissues to function and regenerate in aged organisms. Nicotinamide phosphoribosyltransferase (Nampt) is a crucial enzyme incorporated in cellular senescence, and it plays a vital role in… Continue reading NAD⁺ Regulating Enzyme Keeps Mouse Cells Replicating Under Stress
Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments
Chimeric antigen receptor (CAR) T cells, genetically altered immune cells extracted from patients and subsequently reintroduced, have obtained notoriety for treating blood malignancies. However, is it possible to utilize these cells to combat conditions like aging? In a study published in the journal Nature, Lowe and colleagues from Sloan Kettering Institute in New York demonstrated… Continue reading Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments
Harvard Researchers Link Death from Sleep Deprivation to the Gut
Key Points About one-third of people don’t attain the Center for Disease Control’s recommended seven hours or more of sleep per night. At the same time, very few of us experience the paranoia and disorientation that goes along with extreme sleep deprivation. In rare circumstances, prolonged sleep loss leads to death, leading researchers to question… Continue reading Harvard Researchers Link Death from Sleep Deprivation to the Gut
Keeping the Mouse Body Clock Young to Counter Aging Requires NAD⁺
Circadian rhythms—physiological changes that follow a daily cycle, like the sleep-wake cycle—get disrupted as we get older, which can contribute to the development of age-related diseases. However, the mechanisms and signals linking circadian rhythms and aging are unclear. A research team from Northwestern University published an article in the journal Molecular Cell showing that the… Continue reading Keeping the Mouse Body Clock Young to Counter Aging Requires NAD⁺