Key Points: 500 mg of NR supplementation for ten days reduces oxidative stress and increases exercise performance in old but not young men. Reduced oxidative stress and enhanced physical performance in older men may be due to increased NADH and NADPH. NAD+ is an important molecule that keeps our cells, organs, and bodies alive. Because… Continue reading Clinical Study Suggests When to Start Taking NAD⁺ Boosters to Improve Exercise
Category: Aging & Longevity
Caloric Restriction Decreases Inflammation in Humans
Highlights: Restricting caloric intake by 14% prevents the shrinkage of the thymus, an immune system organ that deteriorates with aging. The immune system of fat tissue is less inflammatory in calorically restricted participants. A gene called PLA2G7 mediates the benefits of caloric restriction and is a potential mimetic of caloric restriction. Whether eating fewer calories… Continue reading Caloric Restriction Decreases Inflammation in Humans
“Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
Highlights A DNA variant in the gene BPIFB4 is shared amongst long-living individuals. This longevity linked DNA variant eliminates senescent cells and rejuvenates NAD+ levels in mice. Long-living individuals, especially those with the longevity variant in BPIFB4, have higher NAD+ levels than elderly adults. What makes us live longer? The food we eat, the amount… Continue reading “Longevity Gene” Revitalizes Multiple Organs and Restores NAD+
David Sinclair: How to Change Your Diet to Live Longer
Highlights: In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant… Continue reading David Sinclair: How to Change Your Diet to Live Longer
Probiotic Improves Healthspan in Multiple Organisms
Highlights: A species of gut bacteria called B. adolescentis declines with aging in humans. Supplementation with B. adolescentis reverses osteoporosis, neurodegeneration, and other age-related conditions in mice. B. adolescentis could potentially be used as a probiotic to slow down the process of aging. Trillions of microscopic organisms live within our gut. Most of these microorganisms… Continue reading Probiotic Improves Healthspan in Multiple Organisms
Using Metabolites in Saliva, Japanese Researchers Measure Aging
Key Points: · Teruya and colleagues identify 21 age-linked compounds in human saliva. · Only one metabolite increased in older subjects: ATP, the cell’s energy currency.· Saliva from older subjects had lower levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. Throughout the COVID-19 pandemic, many people have monitored their ability to taste,… Continue reading Using Metabolites in Saliva, Japanese Researchers Measure Aging
Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy
Highlights A genome-wide CRISPR-Cas9-based screen was utilized by Wang et al. to locate genes that could affect cellular senescence. KAT7 was shown to be a promoter of senescence in stem cells of adult humans. Extension of mice life span and rejuvenation of premature aged progeroid humans cells resulted from inactivation of KAT7. While we… Continue reading Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy
How Does Space Travel Affect Natural Aging?
Growing older can take a serious toll on the body. Bones become brittle, muscle shrinks, the immune system loses strength, and age-related ailments like arthritis can set in. More serious complications like declining cognitive function and heart disease can also take hold as the later years of life progress. These symptoms can also come from… Continue reading How Does Space Travel Affect Natural Aging?
Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner
Highlights Male mouse survival is significantly enhanced through late-life rapamycin administration regimens. Female mouse survival was also improved through continuous rapamycin administration. As males and females have different life expectancies, there are likely to be aging variations between them. However, it is still unclear if there is a connection between these variations in aging and… Continue reading Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner
Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity
The transferring of electrons via metabolic pathways is essential to produce the energy required for human cells to function. To preserve this vital energy-producing process, electrons bind to nicotinamide adenine dinucleotide (NAD+), a crucial compound for cellular metabolism, and convert it to NADH. However, as humans age, the concentration of electrons and the ratio of… Continue reading Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity