Key Points: In fruit flies, rapamycin-induced improvements in gut health, and slightly increased lifespan are due to increased histones – proteins that help maintain the compact organization of DNA in the cell nucleus. Rapamycin also increases histone levels and reorganizes DNA in the small intestines of mice. We are made of cells, most of which… Continue reading Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA
Category: Aging & Longevity
Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
Key Points: Sperm exposure to metformin — a diabetes medication — three months before conception leads to increased birth defects. The frequency of metformin-induced birth defects was higher than birth defects from treatment with insulin or the type 2 diabetes medication sulfonylurea. Conception during metformin exposure was less likely to result in male offspring. When… Continue reading Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
Chinese Medicinal Compound Corylin Shown to Increase Longevity
Key Points: A component called corylin found in a plant used in traditional Chinese medicine increases the replicative lifespan of yeast. Mice fed a high-fat diet with corylin had increased survival and did not have as much age-related functional degeneration as their counterparts. Corylin also decreased senescence in human cells. For thousands of years, the… Continue reading Chinese Medicinal Compound Corylin Shown to Increase Longevity
NAD⁺ Restores Essential Clock for Muscle Repair
Key Points: Circadian clock malfunction hinders muscle repair by inhibiting the formation of new muscle cells after injury. Dysfunctional muscle formation is due to a shift from glucose to fat metabolism, reducing NAD+ levels. Boosting NAD+ restores SIRT1 gene modulation and muscle cell formation. Molecular clocks control many of our body’s biological processes, from our… Continue reading NAD⁺ Restores Essential Clock for Muscle Repair
Mayo Study Shows Senolytics Increase Anti-Aging Protein
Key Points: Senescent cells — an aging-linked state of permanent cell cycle arrest — from various human tissues reduce levels of the anti-aging protein α-klotho. Senolytics — compounds targeting and removing senescent cells — boost α-klotho levels in aged, obese, and senescent cell-transplanted mice. Urinary α-Klotho may be a valuable test for following treatments in… Continue reading Mayo Study Shows Senolytics Increase Anti-Aging Protein
Study Shows Organs Can Age at Different Speeds
Key Points: Our organs are like parts of a biological machine, working together to keep us alive. If one part of the machine becomes old and damaged, the whole machine can break down. To help prevent this inevitable system failure, we can assess the condition of each part. We could even predict how long the… Continue reading Study Shows Organs Can Age at Different Speeds
Cellular Rejuvenation Therapy Safely Reverses Mouse Aging
Key Points: The activation of reprogramming factors – proteins that can turn mature cells back into stem cells – in mice safely rejuvenates skin and kidneys. The rejuvenating effects reduce the activation of genes involved in several age-related pathways, including inflammation, stress, and senescence. The clocks of aging, as measured by changes to patterns in… Continue reading Cellular Rejuvenation Therapy Safely Reverses Mouse Aging
Mayo Clinic Finds That Inhibiting NAD+ Breakdown Increases Lifespan and Prevents Age-Related Physical Decline in Mice
Key Points: The CD38 inhibitor 78c increases the longevity of male but not female mice. The age-related decline in exercise performance is prevented by 78c in the diet. Feeding mice 78c improves several age-related conditions and increases NAD+ levels in multiple organs. NAD+ (nicotinamide adenine dinucleotide) declines with aging in parallel with the health of… Continue reading Mayo Clinic Finds That Inhibiting NAD+ Breakdown Increases Lifespan and Prevents Age-Related Physical Decline in Mice
Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Key Points: When people experience serious adversity, particularly a natural disaster, it can appear as if they’ve aged rapidly. New research shows that a survivor’s superficial and emotional wear and tear are might actually reflect what’s going on inside as natural disasters accelerate biological aging at the DNA level. In a new study published in… Continue reading Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging
Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice
Key Points: Obesity due to a high-fat diet causes subfertility – fewer mature oocytes (eggs) and smaller litters in mice. Supplementing with nicotinamide riboside (NR), an NAD+ precursor, alleviates the obesity-induced subfertility. These findings suggest that NAD+ boosting through precursor supplementation could be a potential therapy for diet-induced subfertility. Infertility is on the rise, currently… Continue reading Study Shows that NAD⁺ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice