Key Points: Oxidative stress opens the door to a myriad of biological complications, including damage to proteins and DNA. While our cells harness antioxidant defenses capable of neutralizing oxidative stress-inducing compounds, time fights back, tipping the scales and leading to oxidants outnumbering antioxidants in the aging brain. As oxidative damage builds up with age, we… Continue reading Study Shows Lion’s Mane Restores Physical Performance in Aged Mice
Category: Aging & Longevity
NAD⁺ Drip Therapy | Does it Work?
Key Points: NAD⁺ (nicotinamide adenine dinucleotide) IV (intravenous) therapy, also known as NAD⁺ drip therapy, refers to injecting NAD⁺ (dissolved in fluid) into an individual’s vein to raise the concentration of NAD⁺ in the bloodstream to receive the therapeutic benefits of NAD⁺. Due to the headaches and shortness of breath that some individuals experience with… Continue reading NAD⁺ Drip Therapy | Does it Work?
Regular Ginseng Use Linked to Reduced Mortality Among Chinese Women
When consumed for a prolonged period – more than three years – ginseng is associated with decreased all-cause mortality, death due to cardiovascular disease, and death due to other diseases. Ginseng has long been touted as a health food supplement, traditionally accepted as a panacea for illness and disease. However, claims of its ability… Continue reading Regular Ginseng Use Linked to Reduced Mortality Among Chinese Women
Scientists Genetically Reprogram Human Skin Cells to be 30 Years Younger
Key Points: A new method of genetic reprogramming rejuvenates skin cells by 30 years, importantly, without losing their identity. Rejuvenated skin cells produce more collagen and heal faster, signs of younger skin. This reprogramming method could potentially be used to treat multiple age-related diseases, including Alzheimer’s disease and cataracts. If you could rewind the age… Continue reading Scientists Genetically Reprogram Human Skin Cells to be 30 Years Younger
Large-Scale Study Shows that Unhealthy Plant-Based Diet Associated with Decreased Lifespan in Older Adults from China
Key Points: Older adults with unhealthy plant-based diets have an increased risk of mortality, while older adults with healthy plant-based diets have lower risks. Fresh fruits and vegetables, legumes, garlic, nuts, and tea are associated with a lower risk of mortality. Preserved vegetables — such as those pickled with salt and brine — and sugar… Continue reading Large-Scale Study Shows that Unhealthy Plant-Based Diet Associated with Decreased Lifespan in Older Adults from China
Gut Bacteria Drive Age-related Immune Changes in the Brain
Key Points: CML, a metabolite, increases within microglia with age, leading to increased cellular stress, decreased mitochondrial function, and decreased cellular energy. The gut bacteria (the intestinal microbiome) profile changes with age leading to increased intestinal permeability. These intestinal permeability changes drive the accumulation of CML within the brain and bloodstream. Numerous studies of the… Continue reading Gut Bacteria Drive Age-related Immune Changes in the Brain
Lowest Dementia Rates Found in Indigenous Amazonians Living Minimalist Lifestyle
Key Points: Dementia prevalence in Tsimane and Moseten, two indigenous groups residing in the Bolivian Amazon, is among the lowest in the world. Physical endurance and cardiovascular fitness obtained from hunting and agricultural work likely contributes to improved cognitive health. Lack of high-fat diets and access to processed foods reduce the risk for cognitive impairment. … Continue reading Lowest Dementia Rates Found in Indigenous Amazonians Living Minimalist Lifestyle
Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA
Key Points: In fruit flies, rapamycin-induced improvements in gut health, and slightly increased lifespan are due to increased histones – proteins that help maintain the compact organization of DNA in the cell nucleus. Rapamycin also increases histone levels and reorganizes DNA in the small intestines of mice. We are made of cells, most of which… Continue reading Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA
Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
Key Points: Sperm exposure to metformin — a diabetes medication — three months before conception leads to increased birth defects. The frequency of metformin-induced birth defects was higher than birth defects from treatment with insulin or the type 2 diabetes medication sulfonylurea. Conception during metformin exposure was less likely to result in male offspring. When… Continue reading Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects
Chinese Medicinal Compound Corylin Shown to Increase Longevity
Key Points: A component called corylin found in a plant used in traditional Chinese medicine increases the replicative lifespan of yeast. Mice fed a high-fat diet with corylin had increased survival and did not have as much age-related functional degeneration as their counterparts. Corylin also decreased senescence in human cells. For thousands of years, the… Continue reading Chinese Medicinal Compound Corylin Shown to Increase Longevity