Key Points: Chloroquine revitalizes prematurely aged human stem cells. Treatment with chloroquine prolongs rat lifespan and reduces age-related damage to multiple organs. Age-related genetic changes are reversed with chloroquine treatment. Chloroquine has long been used to treat malaria and other viral infections, which may be why former President Donald Trump once promoted chloroquine for the… Continue reading Study Shows Chloroquine Extends Lifespan and Rejuvenates Multiple Organs
Category: Aging & Longevity
Israeli Researchers Grow Embryo with Beating Heart in Breakthrough Study
Key Points: Synthetic embryos were successfully grown from mouse embryonic stem cells. These embryos reached stages of development that feature a functioning heart. The synthetically grown mouse embryos show similar physical and genetic features to naturally grown embryos. What if you could age gracefully by having new organs provided to us from a Petri dish?… Continue reading Israeli Researchers Grow Embryo with Beating Heart in Breakthrough Study
French Scientists Show Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease
Key Points: While breaking the spell of aging is a ceaseless endeavor, scientists are getting closer to making age reversal a reality with cellular reprogramming. Cellular reprogramming has captured the imaginations of many for its remarkable age-reversing capabilities, including reversing the biological age of human cells by about 30 years. Now, scientists are perfecting the… Continue reading French Scientists Show Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease
Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence
Key Points: Blood from older adults induces senescence — a cellular state known to underlie the aging process — in human cells. In addition to inducing senescence, transferring blood from old to young mice leads to premature aging of the liver, kidneys, and muscle. Senolytics — drugs that eliminate senescent cells — reverse liver, kidney,… Continue reading Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence
New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
Key Points: Our genetic blueprints (DNA) are constantly being studied to identify longevity-linked genes and pathways that may hold the key to prolonging our lifespan. One particular gene that has strong ties to longevity is Cisd2. In addition to extending the lifespan of rodents through increased activity, activation of Cisd2 protects against cardiac dysfunction and… Continue reading New Longevity Molecule Found to Prolong Lifespan and Delay Cardiac and Muscle Aging
The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis
Key Points: The senolytic ABT-263 enhances the ability of mesenchymal stem cells (MSCs) to generate cartilage, the deterioration of which leads to arthritis. ABT-263 treatment eliminates senescent cells – non-proliferating cells linked to aging – from MSCs by inducing cell death (apoptosis). MSCs treated with ABT-263 grow into larger colonies, indicating a higher potential to… Continue reading The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis
The Hormone FGF21 can Extend Lifespan through Low-Protein Diet
Key Points: Dietary intervention may be one of the most powerful tools available for increasing lifespan. Previous animal studies have confirmed that diets involving caloric restriction and fasting contribute to improved cognition, better muscle function, and increased lifespan. Additionally, low-protein diets have also been shown to extend lifespan as well as enhance metabolic function in… Continue reading The Hormone FGF21 can Extend Lifespan through Low-Protein Diet
New Intranasal and Injectable Gene Therapy Prolongs Lifespan by 40%
Key Points: TERT gene therapy prolongs the median lifespan of mice by 41.4%, and FST gene therapy increases lifespan by 32.5%. Both TERT- and FST-treated mice exhibit improved physical activity and coordination. Transferring TERT and FST into aged mice reduces hair and weight loss. Our DNA holds the blueprint for all our potentially activated or… Continue reading New Intranasal and Injectable Gene Therapy Prolongs Lifespan by 40%
Study Shows Time-Restricted Feeding Enhances Longevity Benefits of Caloric Restriction in Mice
Key Points: Circadian alignment — aligning feeding time with circadian rhythms — combined with caloric restriction prolongs lifespan further than caloric restriction alone. Twelve hours (vs. twenty-two hours) of circadian-aligned fasting is sufficient to extend lifespan. Circadian alignment and caloric restriction restore more age-related gene changes than caloric restriction alone. Caloric restriction — reducing food… Continue reading Study Shows Time-Restricted Feeding Enhances Longevity Benefits of Caloric Restriction in Mice
Obesity Associated with Impaired Sperm Cell Development in Older Males
Key Points: Obese older males have fewer sperm stem cells and impaired sperm development compared to non-obese older males. Age-related changes in non-sperm (somatic) teste cells, including increased inflammation, may impair sperm development in older males. As having children gets pushed to the wayside in lieu of career advancement and the obesity epidemic rages on,… Continue reading Obesity Associated with Impaired Sperm Cell Development in Older Males