Key Points: The human body is multifaceted and complex, housing a myriad of unique molecules that regulate homeostasis and promote survival. From our diverse pool of cellular health regulators, a family of seven enzymes called sirtuins has emerged as key proteins intricately linked to biological processes that affect metabolism, aging, and longevity. Namely, evidence indicates… Continue reading Sirtuins, NAD⁺, Lifespan Extension, and Aging
Category: Aging & Longevity
Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic
Key Points: Our cells aren’t perfect, and as we grow, they incur damage that can downgrade them to senescent cells. Senescent cells secrete pro-inflammatory and tissue-degrading molecules that some propose is the cause of aging. This is why senolytics, which selectively remove senescent cells, are being feverishly tested for their age-countering effects. However, current senolytics… Continue reading Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic
FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%
Key Points: Researchers may have discovered a pill that can increase human lifespan by 10%, or 7 to 8 years. A new study suggests that such a pill could soon be headed for clinical testing, as researchers from the University of Auckland, New Zealand, show that supplementing food with an FDA-approved compound called alpelisib can… Continue reading FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%
Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency
Key Points Studies examining how gene activity fluctuations over an organism’s lifespan affect aging have focused on the abundance of mRNA transcripts. Yet this method of analysis is limited by not looking at specific features of gene activity that may affect how all genes within cells – the genome – are converted to proteins. This… Continue reading Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency
Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator
Key Points: Growth hormone (a.k.a. human growth hormone) secretion declines with age and is associated with multiple aging effects, including diminished vitality and physical activity, muscle loss, and cardiovascular complications. However, scientists can now reduce these effects of aging in mice with peptides that stimulate growth hormone secretion. Xiang and colleagues from Zhejiang University in… Continue reading Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator
New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging
Key Points: Stem cells have continuously been touted as a promising aging intervention, as they hold self-renewal and anti-inflammatory properties that contribute to organ rejuvenation and immune system regulation. However, stem cell therapy requires some refinement before it can be widely used. Recently, scientists have honed in on small fat packets secreted from stem cells… Continue reading New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging
Scientists Find Probiotic Improves Longevity of Mice
Key Points: Old mice supplemented with Akkermansia muciniphila (AKK) for a month live longer. AKK treatment rejuvenates coordination and strength while alleviating anxiety. Treatment heightens the immune response and reduces inflammation and cellular (oxidative) stress. Health maintenance arises through various bodily systems, all of which slowly deteriorate as we age. If these systems, including the… Continue reading Scientists Find Probiotic Improves Longevity of Mice
Baylor College Scientists Increase Lifespan and Attenuate Aging Hallmarks with Antioxidant Cocktail
Key Points: The harmonious balance between oxidants and antioxidants is vital to sustaining cellular functions critical for longevity. One way our bodies achieve this equilibrium is through the abundant antioxidant glutathione (GSH). GSH depletes upon aging and contributes to the onset of multiple aging hallmarks, namely mitochondrial dysfunction, oxidative stress, and DNA damage. Fortunately, scientists… Continue reading Baylor College Scientists Increase Lifespan and Attenuate Aging Hallmarks with Antioxidant Cocktail
Scientists Prolong Mouse Lifespan by Extending Telomeres
Key Points: The shortening of telomeres induces senescence — aged, non-proliferating (senescent) cells that contribute to age-related disease. Restoring telomere length in aged human cells reduces the spread of senescence. Telomere restoration therapy extends the lifespan of aged mice by 20%. Our telomeres shorten as we age, causing our DNA repair systems to malfunction. In… Continue reading Scientists Prolong Mouse Lifespan by Extending Telomeres
Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth
Key Points: Early life (EL) rapamycin treatment increases lifespan by 10% but inhibits growth in male mice. Treatment with rapamycin early in life preserves muscle function. Male mice that undergo EL rapamycin treatment exhibit gene profiles consistent with other potent longevity interventions: caloric restriction and growth hormone deficiency. Identifying potent longevity interventions can be quite… Continue reading Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth