Category: Aging & Longevity

Key Points: Old mice supplemented with Akkermansia muciniphila (AKK) for a month live longer.  AKK treatment rejuvenates coordination and strength while alleviating anxiety. Treatment heightens the immune response and reduces inflammation and cellular (oxidative) stress.  Health maintenance arises through various bodily systems, all of which slowly deteriorate as we age. If these systems, including the… Continue reading Scientists Find Probiotic Improves Longevity of Mice

Key Points:  The harmonious balance between oxidants and antioxidants is vital to sustaining cellular functions critical for longevity. One way our bodies achieve this equilibrium is through the abundant antioxidant glutathione (GSH). GSH depletes upon aging and contributes to the onset of multiple aging hallmarks, namely mitochondrial dysfunction, oxidative stress, and DNA damage. Fortunately, scientists… Continue reading Baylor College Scientists Increase Lifespan and Attenuate Aging Hallmarks with Antioxidant Cocktail

Key Points:  The shortening of telomeres induces senescence — aged, non-proliferating (senescent) cells that contribute to age-related disease.  Restoring telomere length in aged human cells reduces the spread of senescence.  Telomere restoration therapy extends the lifespan of aged mice by 20%. Our telomeres shorten as we age, causing our DNA repair systems to malfunction. In… Continue reading Scientists Prolong Mouse Lifespan by Extending Telomeres

Key Points:  Early life (EL) rapamycin treatment increases lifespan by 10% but inhibits growth in male mice.  Treatment with rapamycin early in life preserves muscle function.  Male mice that undergo EL rapamycin treatment exhibit gene profiles consistent with other potent longevity interventions: caloric restriction and growth hormone deficiency.  Identifying potent longevity interventions can be quite… Continue reading Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Key Points: Chloroquine revitalizes prematurely aged human stem cells. Treatment with chloroquine prolongs rat lifespan and reduces age-related damage to multiple organs.  Age-related genetic changes are reversed with chloroquine treatment. Chloroquine has long been used to treat malaria and other viral infections, which may be why former President Donald Trump once promoted chloroquine for the… Continue reading Study Shows Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Key Points:  Synthetic embryos were successfully grown from mouse embryonic stem cells. These embryos reached stages of development that feature a functioning heart. The synthetically grown mouse embryos show similar physical and genetic features to naturally grown embryos. What if you could age gracefully by having new organs provided to us from a Petri dish?… Continue reading Israeli Researchers Grow Embryo with Beating Heart in Breakthrough Study

Key Points:  While breaking the spell of aging is a ceaseless endeavor, scientists are getting closer to making age reversal a reality with cellular reprogramming. Cellular reprogramming has captured the imaginations of many for its remarkable age-reversing capabilities, including reversing the biological age of human cells by about 30 years. Now, scientists are perfecting the… Continue reading French Scientists Show Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease

Key Points:  Blood from older adults induces senescence — a cellular state known to underlie the aging process — in human cells.  In addition to inducing senescence, transferring blood from old to young mice leads to premature aging of the liver, kidneys, and muscle.  Senolytics — drugs that eliminate senescent cells — reverse liver, kidney,… Continue reading Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence