Key Points Calorie restriction, which has been shown to slow aging in animals, showed signs of slowing biological aging in the first-ever study of the effects of long-term calorie restriction on healthy, non-obese humans, shows a study published in Nature Aging. The two-year Phase 2 randomized controlled trial found that the intervention effect represented a… Continue reading Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults
Category: Aging & Longevity
Longevity Interventions for Age-Related DNA Changes
Key Points: All humans age, and yet the rates of age-related illness and mortality are vastly different across populations. Many researchers believe that some of these age-related differences can be attributed to epigenetic changes – modifications that change how our DNA is expressed in our cells. Epigenetics helps link our genome (DNA) to the way… Continue reading Longevity Interventions for Age-Related DNA Changes
Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging
Key Points The majority of genetics studies analyzing aging determinants have looked at protein-coding genes, but non-coding DNA regions are beginning to garner attention. One so-called non-coding region is the endogenous retrovirus (ERV) – a DNA sequence relic of an ancient viral infection. Comprising ~8% of our genomes, these viral insertions of DNA sequences have… Continue reading Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging
New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut
Key Points: It is becoming increasingly clear that our gut microbiota — bacteria and other microorganisms that live in our gut — could contribute to how fast we age. Some gut bacteria are beneficial (probiotics), while others are harmful, and our diet can influence which gut microbiota reside in our body. Now, researchers from Tsinghua University… Continue reading New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut
Sirtuins, NAD⁺, Lifespan Extension, and Aging
Key Points: The human body is multifaceted and complex, housing a myriad of unique molecules that regulate homeostasis and promote survival. From our diverse pool of cellular health regulators, a family of seven enzymes called sirtuins has emerged as key proteins intricately linked to biological processes that affect metabolism, aging, and longevity. Namely, evidence indicates… Continue reading Sirtuins, NAD⁺, Lifespan Extension, and Aging
Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic
Key Points: Our cells aren’t perfect, and as we grow, they incur damage that can downgrade them to senescent cells. Senescent cells secrete pro-inflammatory and tissue-degrading molecules that some propose is the cause of aging. This is why senolytics, which selectively remove senescent cells, are being feverishly tested for their age-countering effects. However, current senolytics… Continue reading Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic
FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%
Key Points: Researchers may have discovered a pill that can increase human lifespan by 10%, or 7 to 8 years. A new study suggests that such a pill could soon be headed for clinical testing, as researchers from the University of Auckland, New Zealand, show that supplementing food with an FDA-approved compound called alpelisib can… Continue reading FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%
Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency
Key Points Studies examining how gene activity fluctuations over an organism’s lifespan affect aging have focused on the abundance of mRNA transcripts. Yet this method of analysis is limited by not looking at specific features of gene activity that may affect how all genes within cells – the genome – are converted to proteins. This… Continue reading Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency
Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator
Key Points: Growth hormone (a.k.a. human growth hormone) secretion declines with age and is associated with multiple aging effects, including diminished vitality and physical activity, muscle loss, and cardiovascular complications. However, scientists can now reduce these effects of aging in mice with peptides that stimulate growth hormone secretion. Xiang and colleagues from Zhejiang University in… Continue reading Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator
New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging
Key Points: Stem cells have continuously been touted as a promising aging intervention, as they hold self-renewal and anti-inflammatory properties that contribute to organ rejuvenation and immune system regulation. However, stem cell therapy requires some refinement before it can be widely used. Recently, scientists have honed in on small fat packets secreted from stem cells… Continue reading New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging