Key Points In a new paper in Nature Aging called “Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish,” researchers say that “gut-specific rescue of telomerase activation leading to telomere elongation is sufficient to systemically counteract aging in zebrafish.” The key word in that sentence is “rescue,” which means that the experiments were done on… Continue reading Study Shows Telomerase Activation in Gut Has Limited Anti-Aging Effects on Healthy Fish
Category: Aging & Longevity
The Emergence of Cellular Reprogramming: True Age Reversal Technology
Contents Why Do We Age? Reversing Aging with Cellular Reprogramming How Does Cellular Reprogramming Work? Biological Clocks Partial Epigenetic Reprogramming Delivering Yamanaka Factors via Gene Therapy How Effective is Cellular Reprogramming? Reprogramming Extends Mouse Lifespan Reprogramming Reverses Aging When will Cellular Reprogramming Reach Consumers? Why Do We Age? Scientists are unable to agree upon the… Continue reading The Emergence of Cellular Reprogramming: True Age Reversal Technology
NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels
Contents What Does NAD+ Do? Effects of Restoring NAD+ with Its Precursors NAD+ Precursor Clinical Trials NMN NR Nicotinamide Niacin Tryptophan Choosing and Obtaining NAD+ Precursors The reduction of nicotinamide adenine dinucleotide (NAD+) with age leads to declining cellular energy production and increases inflammation. These factors lead to accelerated aging and an increased incidence of… Continue reading NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels
Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization
Contents Introduction: What are senolytics? Examples of senolytics and their current data Active and Planned Senolytic Human Trials Commercially available senolytics As we grow older, the number of aged, non-proliferative senescent cells that release a milieu of inflammatory molecules to surrounding cells increases throughout our bodies. The molecule combination that senescent cells release (the senescence-associated… Continue reading Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization
Scientists Successfully Increase Lifespan and Delay Brain Aging with New Prebiotic
Key Points: Our gut microbiome – an internal hub housing trillions of nutrient-boosting microorganisms, including bacteria and other microbes – is emerging as a central modulator of health and wellness. Studies have linked poor gut health to a myriad of harmful aged-related conditions like diabetes, cancer, and central nervous system complications that affect the brain.… Continue reading Scientists Successfully Increase Lifespan and Delay Brain Aging with New Prebiotic
Latest German Study: Calorie Restriction Reverses Fast and Clumsy DNA Reading During Aging
Key Points Aging affects numerous cellular processes, including the quality and concentration of proteins within cells. DNA transcription constitutes one of the essential steps in protein production from DNA sequences; however, it’s currently unknown to what extent transcription contributes to or is affected by aging. Published in Nature, Beyer and colleagues from the University of… Continue reading Latest German Study: Calorie Restriction Reverses Fast and Clumsy DNA Reading During Aging
Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults
Key Points Calorie restriction, which has been shown to slow aging in animals, showed signs of slowing biological aging in the first-ever study of the effects of long-term calorie restriction on healthy, non-obese humans, shows a study published in Nature Aging. The two-year Phase 2 randomized controlled trial found that the intervention effect represented a… Continue reading Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults
Longevity Interventions for Age-Related DNA Changes
Key Points: All humans age, and yet the rates of age-related illness and mortality are vastly different across populations. Many researchers believe that some of these age-related differences can be attributed to epigenetic changes – modifications that change how our DNA is expressed in our cells. Epigenetics helps link our genome (DNA) to the way… Continue reading Longevity Interventions for Age-Related DNA Changes
Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging
Key Points The majority of genetics studies analyzing aging determinants have looked at protein-coding genes, but non-coding DNA regions are beginning to garner attention. One so-called non-coding region is the endogenous retrovirus (ERV) – a DNA sequence relic of an ancient viral infection. Comprising ~8% of our genomes, these viral insertions of DNA sequences have… Continue reading Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging
New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut
Key Points: It is becoming increasingly clear that our gut microbiota — bacteria and other microorganisms that live in our gut — could contribute to how fast we age. Some gut bacteria are beneficial (probiotics), while others are harmful, and our diet can influence which gut microbiota reside in our body. Now, researchers from Tsinghua University… Continue reading New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut