Key Points: Our senses allow us to formulate our perceptions of the world, with each sense adding a unique layer to the bigger picture. Unfortunately, our sense of hearing gets hit the hardest as we age, increasing the risk of age-related cognitive decline and dementia. Although treatments for age-related hearing loss (ARHL) are extremely limited,… Continue reading NIA Researchers Show NR Halts Age-Related Hearing Loss
Category: NR
NR Reduces Stroke-Induced Brain Damage, Study Finds
Key Points: When our arteries are blocked, the life-sustaining oxygen and nutrients within our blood cannot reach our cells, leading quickly to cellular energy reductions and cell death. This blocking of the arteries and lack of blood flow that often occurs with aging is called an ischemic stroke and if it occurs in the hippocampus… Continue reading NR Reduces Stroke-Induced Brain Damage, Study Finds
Challenges to the Validity of Patent for Nicotinamide Riboside Production
The presence of cellular nicotinamide adenine dinucleotide (NAD+), a compound critical for health and longevity, is known to decline as humans age. However, direct consumption of NAD+ lacks efficiency in restoring NAD+ within cells. Instead, a more effective method of boosting NAD+ involves utilizing precursor molecules of NAD+. Thus, there is widespread interest and competition… Continue reading Challenges to the Validity of Patent for Nicotinamide Riboside Production
Preliminary Clinical Trial Data Shows NAD⁺ Improves Inflammatory Response in Heart Failure
Although the immune system utilizes inflammation as a method to restore health in the body, there is evidence suggesting that inflammation may be linked to progressive heart failure. Immune cells that facilitate this process highly rely on the mitochondria, the powerhouse of the cell, to provide energy. However, researchers still don’t know whether malfunctional mitochondria… Continue reading Preliminary Clinical Trial Data Shows NAD⁺ Improves Inflammatory Response in Heart Failure
NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term
When kidneys become damaged and can no longer filter blood properly, humans become susceptible to developing kidney disease. This has often been linked to malfunctional mitochondria, the cell’s power generator, and a reduction in the concentration of cellular nicotinamide adenine dinucleotide (NAD+), a vital compound that fuels functional mitochondria. However, there is no apparent connection… Continue reading NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term
Increasing NAD⁺ levels May Bolster Innate Immunity to Coronaviruses
Coronavirus genomes, which contain the instructions for constructing and assembling the virus, lack the ability to encode enzymes required for energy production and the generation of biological building blocks. Thus, the assembly of these viruses is dependent on the utilization of infected host cell processes. The viral genome-encoded processes for energy production and the generation… Continue reading Increasing NAD⁺ levels May Bolster Innate Immunity to Coronaviruses
NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
T lymphocytes, a type of white blood cell, contribute to the body’s immune response against cancer. T lymphocyte antitumor responses are metabolically challenged when nutrients are depleted from the cellular microenvironment that tumors form, resulting in T cell malfunction. Researchers have yet to elucidate the mechanisms controlling the effects tumors have on T lymphocyte antitumor… Continue reading NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
Repetitive DNA strands called telomeres stop chromosome ends from fraying or sticking to each other, similar to plastic tips at the ends of shoelaces. These protective ends also ensure DNA gets copied correctly during cell replication. The length of telomeres is closely linked to aging, and when telomere length gets whittled down, cells age faster.… Continue reading Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation
Aging and obesity increase the risk of humans developing onset atrial fibrillation, a condition where the upper (atria) and lower (ventricles) chambers of the heart have unsynchronized beating rhythms. Atrial fibrillation is the most prevalent issue pertaining to the rate or rhythm of the heartbeat, and it is known to affect over 33 million people… Continue reading The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation
Challenges to the Current Thinking on Supplementing with NR
Many studies over the last few decades support the notion that declining function of the cell’s power-generating structure, the mitochondria, is linked with obesity, insulin resistance, and type 2 diabetes for rodent and human tissues. Studies have also shown metabolic impairments that come from diminished levels of a molecule called nicotinamide adenine dinucleotide (NAD+) that… Continue reading Challenges to the Current Thinking on Supplementing with NR