Key Points: Researchers from Sun Yat-sen University in Guangzhou, China, published results showing that taking NAD+ precursors stopped liver cancer from causing weight loss and metastasis. Liver cancer is the sixth most common cancer in the world and was the third leading cause of cancer-related deaths worldwide in 2020. In different mouse models of hepatocellular… Continue reading Study Reveals NR Slows Liver Cancer Progression in Mice
Category: NR
Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury
Key Points: Dysfunction of the semipermeable barrier between the inside of the intestines and the blood supply (the intestinal barrier) has been shown to be implicated in inflammaging – the age-related increase in proinflammatory cell signals and markers. A new study shows that supplementing with nicotinamide riboside (NR) – an NAD+ precursor – may help… Continue reading Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury
Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model
Key Points Research has already shown that treating mouse models of kidney disease with NAD+ precursors like NMN prevents kidney damage and improves kidney function. However, no direct comparison between the efficacy of NMN and another potent NAD+ precursor – NR – have been performed until now. NR must be converted to NMN before transforming… Continue reading Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model
National Institute on Aging Scientists Restore Age-Related Smell Loss with NAD⁺ Booster
Key Points: A little-known side effect of aging is loss of smell. Increasing evidence even points to the loss of smell as an early indicator of Alzheimer’s and Parkinson’s disease. Now, scientists from the National Institute of Aging have found that NR may mitigate age-related smell loss. Dan and colleagues report in Aging Cell that… Continue reading National Institute on Aging Scientists Restore Age-Related Smell Loss with NAD⁺ Booster
NR Has Protective Effects Against Chemotherapy-Induced Heart Toxicity: New Study
Key Points: As we age, we are more susceptible to various maladies, including cancer. Cancer can often lead to other concerns due to not just the disease’s symptoms but also the side effects of the myriad of medications used to fight it. Doxorubicin is a strong chemotherapy agent used for multiple types of cancers, including… Continue reading NR Has Protective Effects Against Chemotherapy-Induced Heart Toxicity: New Study
NAD+ Supplement Increases Muscle Mitochondria and Beneficial Gut Bacteria: Finland Study
Highlights Rodent studies suggest that increasing levels of an essential molecule for mitochondrial function, NAD+, combats obesity and its related disorders. Along those lines, supplementing with the NAD+ precursor NR increases mitochondrial production (biogenesis) and function, protects against obesity, and improves the gut’s microbial composition in mice. However, so far, studies in humans haven’t provided… Continue reading NAD+ Supplement Increases Muscle Mitochondria and Beneficial Gut Bacteria: Finland Study
Scientists Find Metformin and NR Comparably Limit Deterioration of Multiple Organs
Key Points: In the world of anti-aging research, two compounds have risen to the forefront. Metformin – a common diabetes medication – and nicotinamide riboside (NR) – an NAD+ precursor – have both been shown to confer numerous anti-aging benefits. A recent study looks at how metformin and NR compare. The study, out of China,… Continue reading Scientists Find Metformin and NR Comparably Limit Deterioration of Multiple Organs
Russia Study Shows Immucillin H Enhances NR’s NAD⁺ Boosting Effect
Key Points: Our cells demand adequate NAD+ levels to fuel enzymes that modulate cell survival. As we age, our cells accumulate damage, namely to DNA, increasing the need for survival enzymes and raising the demand for NAD+. However, when these demands are unmet, cells die, organs degenerate, and disease ensues. This is why replenishing NAD+… Continue reading Russia Study Shows Immucillin H Enhances NR’s NAD⁺ Boosting Effect
Scientists Reduce Cardiac Dysfunction in Diabetes by Boosting NAD⁺
Key Points: Diabetic mice display cardiac dysfunction and mitochondrial impairments. NR supplementation increases cellular NAD+ levels and helps restore mitochondrial function. Restoration of mitochondrial function reduces cellular (oxidative) stress, mediating the repair of cardiac function. Our heart functions to nourish each of our cells, however, its ability to pump nutrients and oxygen can become compromised.… Continue reading Scientists Reduce Cardiac Dysfunction in Diabetes by Boosting NAD⁺
Researchers Show NR Reduces Obesity by Altering Gut Bacteria
Key Points: Obesity, common among Western and elderly populations alike, brings about age-related diseases like type 2 diabetes, cancer, and cardiovascular disease. Since diet and exercise can be difficult for some folks, scientists have been trying to find new ways to alleviate the obesity epidemic. Now, investigators from the Medical College of Wisconsin have gathered… Continue reading Researchers Show NR Reduces Obesity by Altering Gut Bacteria