Contents What Does NAD+ Do? Effects of Restoring NAD+ with Its Precursors NAD+ Precursor Clinical Trials NMN NR Nicotinamide Niacin Tryptophan Choosing and Obtaining NAD+ Precursors The reduction of nicotinamide adenine dinucleotide (NAD+) with age leads to declining cellular energy production and increases inflammation. These factors lead to accelerated aging and an increased incidence of… Continue reading NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels
Category: NR
NR and CoQ10 Improve Kidney Function: Latest Study
Key Points About 15% of US adults have chronic kidney disease, and as many as 90% of adults with chronic kidney disease don’t know they have it. Those with severe kidney disease often suffer from declining muscle function, precipitating frailty for some. Along those lines, researchers propose that declining mitochondrial metabolism facilitates declining physical function… Continue reading NR and CoQ10 Improve Kidney Function: Latest Study
Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases
Key Points: Boosting NAD+ levels improves the health and survival of human brain cells that model neurodegeneration, according to researchers from the Whitehead Institute for Biomedical Research at MIT and the Institute of Cancer and Genomic Sciences at the University of Birmingham in the UK. The authors suggest that intervention with NAD+-boosting agents could have… Continue reading Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases
NAD+ Deficiency in Arthritis Patients Reversed by NMN and NR: Latest Study Findings
Key Points Rheumatoid arthritis, an inflammatory disease where one’s own immune system degrades joints and tendons, affects about 1% to 2% of the US population. Although researchers have linked inflammation to the disease, little is known about underlying factors contributing to it. Moreover, declining NAD+ levels have been tied to numerous age-related diseases, but whether… Continue reading NAD+ Deficiency in Arthritis Patients Reversed by NMN and NR: Latest Study Findings
Study Reveals NR Slows Liver Cancer Progression in Mice
Key Points: Researchers from Sun Yat-sen University in Guangzhou, China, published results showing that taking NAD+ precursors stopped liver cancer from causing weight loss and metastasis. Liver cancer is the sixth most common cancer in the world and was the third leading cause of cancer-related deaths worldwide in 2020. In different mouse models of hepatocellular… Continue reading Study Reveals NR Slows Liver Cancer Progression in Mice
Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury
Key Points: Dysfunction of the semipermeable barrier between the inside of the intestines and the blood supply (the intestinal barrier) has been shown to be implicated in inflammaging – the age-related increase in proinflammatory cell signals and markers. A new study shows that supplementing with nicotinamide riboside (NR) – an NAD+ precursor – may help… Continue reading Study Shows that NR Helps Prevent Alcohol-Induced Gut Injury
Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model
Key Points Research has already shown that treating mouse models of kidney disease with NAD+ precursors like NMN prevents kidney damage and improves kidney function. However, no direct comparison between the efficacy of NMN and another potent NAD+ precursor – NR – have been performed until now. NR must be converted to NMN before transforming… Continue reading Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model
National Institute on Aging Scientists Restore Age-Related Smell Loss with NAD⁺ Booster
Key Points: A little-known side effect of aging is loss of smell. Increasing evidence even points to the loss of smell as an early indicator of Alzheimer’s and Parkinson’s disease. Now, scientists from the National Institute of Aging have found that NR may mitigate age-related smell loss. Dan and colleagues report in Aging Cell that… Continue reading National Institute on Aging Scientists Restore Age-Related Smell Loss with NAD⁺ Booster
NR Has Protective Effects Against Chemotherapy-Induced Heart Toxicity: New Study
Key Points: As we age, we are more susceptible to various maladies, including cancer. Cancer can often lead to other concerns due to not just the disease’s symptoms but also the side effects of the myriad of medications used to fight it. Doxorubicin is a strong chemotherapy agent used for multiple types of cancers, including… Continue reading NR Has Protective Effects Against Chemotherapy-Induced Heart Toxicity: New Study
NAD+ Supplement Increases Muscle Mitochondria and Beneficial Gut Bacteria: Finland Study
Highlights Rodent studies suggest that increasing levels of an essential molecule for mitochondrial function, NAD+, combats obesity and its related disorders. Along those lines, supplementing with the NAD+ precursor NR increases mitochondrial production (biogenesis) and function, protects against obesity, and improves the gut’s microbial composition in mice. However, so far, studies in humans haven’t provided… Continue reading NAD+ Supplement Increases Muscle Mitochondria and Beneficial Gut Bacteria: Finland Study