T lymphocytes, a type of white blood cell, contribute to the body’s immune response against cancer. T lymphocyte antitumor responses are metabolically challenged when nutrients are depleted from the cellular microenvironment that tumors form, resulting in T cell malfunction. Researchers have yet to elucidate the mechanisms controlling the effects tumors have on T lymphocyte antitumor… Continue reading NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
Category: NR
Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
Repetitive DNA strands called telomeres stop chromosome ends from fraying or sticking to each other, similar to plastic tips at the ends of shoelaces. These protective ends also ensure DNA gets copied correctly during cell replication. The length of telomeres is closely linked to aging, and when telomere length gets whittled down, cells age faster.… Continue reading Replenishing NAD⁺ Reduces Cell Defects in Patient with Frayed Chromosome Ends
The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation
Aging and obesity increase the risk of humans developing onset atrial fibrillation, a condition where the upper (atria) and lower (ventricles) chambers of the heart have unsynchronized beating rhythms. Atrial fibrillation is the most prevalent issue pertaining to the rate or rhythm of the heartbeat, and it is known to affect over 33 million people… Continue reading The Nampt/NAD⁺ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation
Challenges to the Current Thinking on Supplementing with NR
Many studies over the last few decades support the notion that declining function of the cell’s power-generating structure, the mitochondria, is linked with obesity, insulin resistance, and type 2 diabetes for rodent and human tissues. Studies have also shown metabolic impairments that come from diminished levels of a molecule called nicotinamide adenine dinucleotide (NAD+) that… Continue reading Challenges to the Current Thinking on Supplementing with NR
NAD⁺ Precursor Improves Neuron Production and Motor Function in Mice with ALS
Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is caused by progressive cell deterioration throughout the nervous system in motor neurons that control our muscle movements, prompting muscle weakness and eventual paralysis. Still, we don’t have effective drugs for treating ALS. The diminishing levels of a vital molecule called nicotinamide adenine dinucleotide (NAD+) is… Continue reading NAD⁺ Precursor Improves Neuron Production and Motor Function in Mice with ALS
Long-Term NR Administration Does Not Improve Mitochondrial Function or Human Skeletal Muscle NAD+ Content
Boosting nicotinamide adenine dinucleotide (NAD+) levels with precursors like nicotinamide riboside (NR) has become popular as a means to fight off age-related diseases that come from dysfunction of the cell’s powerhouse, the mitochondria. Human studies evaluating NR supplementation’s effects have sought to determine whether NR can in fact alleviate and prevent these diseases. Past studies… Continue reading Long-Term NR Administration Does Not Improve Mitochondrial Function or Human Skeletal Muscle NAD+ Content
Vitamin B3 Forms in Dairy Products Identified by New Analtyical Tool
Vitamin B3 is a class of vitamins that comes in three different forms–nicotinamide riboside (NR), niacin (NA), and nicotinamide (NAM)—that are naturally present in some foods, added to foods, and sold as supplements. The vitamin B3 family is involved in important chemical reactions that synthesize nicotinamide adenine dinucleotide (NAD+), a compound that aids enzymes in… Continue reading Vitamin B3 Forms in Dairy Products Identified by New Analtyical Tool