Key Points: Researchers from Beijing demonstrated that a leading cause of kidney injury in pediatric patients is tied to the dysregulation of NAD+. In pediatric patients with obstructive nephropathy, the enzyme CD38, which drains NAD+ supplies, was highly upregulated, and when the researchers blocked CD38 or supplement NAD+ in mice with obstructed kidneys, they observed… Continue reading NAD+ Decline Identified as a Therapeutic Target for Kidney Injury
Category: NAD
NIA Researchers Show NR Halts Age-Related Hearing Loss
Key Points: Our senses allow us to formulate our perceptions of the world, with each sense adding a unique layer to the bigger picture. Unfortunately, our sense of hearing gets hit the hardest as we age, increasing the risk of age-related cognitive decline and dementia. Although treatments for age-related hearing loss (ARHL) are extremely limited,… Continue reading NIA Researchers Show NR Halts Age-Related Hearing Loss
Scientists find NAD⁺ Boosting Enzyme Protects Against Diabetes and Skeletal Muscle Decline
Key Points: The Nampt activator P7C3 lowers blood glucose while increasing insulin-secreting pancreatic β cells in diabetic mice. Treatment with P7C3 increases physical endurance, as well as muscle strength and size. P7C3 raises “good” cholesterol and lowers “bad” cholesterol. As the human population rises and the elderly population expands, unprecedented numbers of individuals with age-related… Continue reading Scientists find NAD⁺ Boosting Enzyme Protects Against Diabetes and Skeletal Muscle Decline
New Study Shows NAD⁺ Nanoparticles Increase Survival from Sepsis by Over Fourfold in Mice
Key Points: Treating septic mice with lipid nanoparticles (NPs) loaded with nicotinamide adenine dinucleotide (NAD+) increases their survival rate from 21% to 93%. Treatment with loaded NPs stops immune cells from dying, blocking the immunosuppressive response caused by sepsis. The primary cell energy currency (ATP) is restored in multiple organs of septic mice following treatment… Continue reading New Study Shows NAD⁺ Nanoparticles Increase Survival from Sepsis by Over Fourfold in Mice
Australian Scientists Find Exercise Boosts NAD⁺ in Young but not Older Adults
Key Points: Twenty minutes of cycling exercise triggers the release of tiny membrane-bound sacs called extracellular vesicles (EVs) containing NAMPT. Post-exercise EVs from fit young males but not young unfit or older males raise NAD+ levels in mouse muscle cells. An enzyme associated with longevity and prolonged lifespan called sirtuin 1 (SIRT1) is increased by… Continue reading Australian Scientists Find Exercise Boosts NAD⁺ in Young but not Older Adults
NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term
When kidneys become damaged and can no longer filter blood properly, humans become susceptible to developing kidney disease. This has often been linked to malfunctional mitochondria, the cell’s power generator, and a reduction in the concentration of cellular nicotinamide adenine dinucleotide (NAD+), a vital compound that fuels functional mitochondria. However, there is no apparent connection… Continue reading NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term
NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
T lymphocytes, a type of white blood cell, contribute to the body’s immune response against cancer. T lymphocyte antitumor responses are metabolically challenged when nutrients are depleted from the cellular microenvironment that tumors form, resulting in T cell malfunction. Researchers have yet to elucidate the mechanisms controlling the effects tumors have on T lymphocyte antitumor… Continue reading NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration
Harvard Researchers Link Death from Sleep Deprivation to the Gut
Key Points About one-third of people don’t attain the Center for Disease Control’s recommended seven hours or more of sleep per night. At the same time, very few of us experience the paranoia and disorientation that goes along with extreme sleep deprivation. In rare circumstances, prolonged sleep loss leads to death, leading researchers to question… Continue reading Harvard Researchers Link Death from Sleep Deprivation to the Gut
Challenges to the Current Thinking on Supplementing with NR
Many studies over the last few decades support the notion that declining function of the cell’s power-generating structure, the mitochondria, is linked with obesity, insulin resistance, and type 2 diabetes for rodent and human tissues. Studies have also shown metabolic impairments that come from diminished levels of a molecule called nicotinamide adenine dinucleotide (NAD+) that… Continue reading Challenges to the Current Thinking on Supplementing with NR
Long-Term NR Administration Does Not Improve Mitochondrial Function or Human Skeletal Muscle NAD+ Content
Boosting nicotinamide adenine dinucleotide (NAD+) levels with precursors like nicotinamide riboside (NR) has become popular as a means to fight off age-related diseases that come from dysfunction of the cell’s powerhouse, the mitochondria. Human studies evaluating NR supplementation’s effects have sought to determine whether NR can in fact alleviate and prevent these diseases. Past studies… Continue reading Long-Term NR Administration Does Not Improve Mitochondrial Function or Human Skeletal Muscle NAD+ Content